BOC-5-METHOXY-L-TRYPTOPHAN

Base Information

• Chemical Name: BOC-5-METHOXY-L-TRYPTOPHAN
• CAS No.: 114903-30-9
• Molecular Formula: C₁₇H₂₂N₂O₅
• Molecular Weight: 334.372
• Hs Code.: 2933990090
• Mol file: 114903-30-9.mol

Synonyms:BOC-5-METHOXY-L-TRYPTOPHAN;N-BOC-5-METHOXY-L-TRYPTOPHAN;L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-5-methoxy-;(S)-2-((tert-Butoxycarbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid

Chemical Property of BOC-5-METHOXY-L-TRYPTOPHAN

Chemical Property:

• Boiling Point: 564.0±50.0 °C(Predicted)
• PKA: 3.84±0.10(Predicted)
• PSA: 100.65000
• Density: 1.261±0.06 g/cm3(Predicted)
• LogP: 3.08780
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Boc-5-methoxy-L-tryptophan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-5-METHOXY-L-TRYPTOPHAN

There total 6 articles about BOC-5-METHOXY-L-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-methoxytryptophan (28052-84-8) → 2-((tert-butoxycarbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid (114873-19-7,114903-30-9,2103356-55-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b02027

Reference yield: 90.0%

→ 2-((tert-butoxycarbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid (114873-19-7,114903-30-9,2103356-55-2)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; at 20 ℃;

Reference yield: 67.0%

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + 5-methoxytryptophan (28052-84-8) → 2-((tert-butoxycarbonyl)amino)-3-(5-methoxy-1H-indol-3-yl)propanoic acid (114873-19-7,114903-30-9,2103356-55-2)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 3h;

DOI:10.15227/orgsyn.063.0171

upstream raw materials:

5-methoxygramine

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

5-methoxytryptophan

di-tert-butyl dicarbonate