2-(2-BroMobenzyloxy)-5-chloroaniline

Base Information

• Chemical Name: 2-(2-BroMobenzyloxy)-5-chloroaniline
• CAS No.: 92022-10-1
• Molecular Formula: C13H11BrClNO
• Molecular Weight: 312.593
• Mol file: 92022-10-1.mol

Synonyms:2-(2-BroMobenzyloxy)-5-chloroaniline

Chemical Property of 2-(2-BroMobenzyloxy)-5-chloroaniline

Chemical Property:

• Boiling Point: 429.3±35.0 °C (760 mmHg)
• PSA: 35.25000
• Density: 1.528±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 4.84490

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-BroMobenzyloxy)-5-chloroaniline

There total 3 articles about 2-(2-BroMobenzyloxy)-5-chloroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-[(2-bromophenyl)methoxy]-4-chloro-2-nitro-benzene (91805-29-7) → 2-[(2-bromophenyl)methoxy]-5-chloro-aniline (92022-10-1)

Guidance literature:

With hydrogenchloride; iron; In isopropyl alcohol; at 60 ℃; for 20.5h;

Reference yield: 83.0%

2-hydroxy-5-chloro-aniline (95-85-2) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 2-[(2-bromophenyl)methoxy]-5-chloro-aniline (92022-10-1)

Guidance literature:

With sodium carbonate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1055/s-2008-1078506

Reference yield:

p-chloro-o-nitrophenol (89-64-5) → 2-[(2-bromophenyl)methoxy]-5-chloro-aniline (92022-10-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / ethanol / Heating

2: Fe, aq. HCl / propan-2-ol / Heating

With hydrogenchloride; potassium hydroxide; iron; In ethanol; isopropyl alcohol;

DOI:10.1021/jm00335a008

upstream raw materials:

1-[(2-bromophenyl)methoxy]-4-chloro-2-nitro-benzene

p-chloro-o-nitrophenol

2-hydroxy-5-chloro-aniline

1-Bromo-2-bromomethyl-benzene

Downstream raw materials:

N-[2-[(2-bromophenyl)methoxy]-5-chloro-phenyl]formamide