3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride

Base Information

Chemical Name:3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride
CAS No.:444057-64-1
Molecular Formula:C₂₄H₂₆N₄O₆S₂*ClH
Molecular Weight:567.087
Hs Code.:
Mol file:444057-64-1.mol

Synonyms:(2S)-cis-3-[[(4-Mercapto-2-pyrrolidinyl)carbonyl]aMino]benzoic Acid Disulfide Dihydrochloride;3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride

Suppliers and Price of 3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S)-cis-3-[[(4-Mercapto-2-pyrrolidinyl)carbonyl]amino]benzoicAcidDisulfideDihydrochloride
50mg
$ 3520.00

Medical Isotopes, Inc.
(2S)-cis-3-[[(4-Mercapto-2-pyrrolidinyl)carbonyl]amino]benzoicAcidDisulfideDiHCl
50 mg
$ 4200.00

Total 2 raw suppliers

Chemical Property of 3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride

Chemical Property:

PSA：214.44000
LogP:4.45920

Purity/Quality:: (2S)-cis-3-[[(4-Mercapto-2-pyrrolidinyl)carbonyl]amino]benzoicAcidDisulfideDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (2S)-cis-3-[[(4-Mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic Acid Disulfide is an impurity of Ertapenem (E635000).

Technology Process of 3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride

There total 7 articles about 3,3'-[Dithiobis[(2S,4S)-4,2-pyrrolidinediylcarbonyliMino]]bisbenzoic Acid Dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 219909-83-8
(2S-cis)-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride

: 444057-64-1
(2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride disulfide

Guidance literature:: In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1021/jo011170c

Reference yield:

: 117286-92-7
N‐(O,O‐diisopropylphosphoryl)-trans-4‐hydroxy-L-proline

: 444057-64-1
(2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride disulfide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 56 percent / (i-Pr)2NEt / CH₂Cl₂ / 0.25 h / -15 °C

2.1: pyridine / CH₂Cl₂ / 0.5 h / -20 °C

3.1: Na₂S*3H₂O / CH₂Cl₂; H₂O / 0.03 h

3.2: 5 g / CH₂Cl₂; H₂O / 2.08 h / 3 - 25 °C

4.1: acetic acid / 20 - 23 °C

5.1: 1.88 kg / conc. HCl / acetic acid / 2 h / 20 - 23 °C

6.1: dimethylsulfoxide / 48 h / 20 °C

With pyridine; hydrogenchloride; sodium sulfide; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetic acid; dimethyl sulfoxide;
DOI:10.1021/jo011170c

Reference yield:

: 99-05-8,159139-79-4
meta-aminobenzoic acid

: 444057-64-1
(2S)-cis-3-[[(4-mercapto-2-pyrrolidinyl)carbonyl]amino]benzoic acid monohydrochloride disulfide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 20 - 23 °C

2: 1.88 kg / conc. HCl / acetic acid / 2 h / 20 - 23 °C

3: dimethylsulfoxide / 48 h / 20 °C

With hydrogenchloride; In acetic acid; dimethyl sulfoxide;
DOI:10.1021/jo011170c