Technology Process of 3-AMino-2,6-dichloroisonicotinic acid
There total 7 articles about 3-AMino-2,6-dichloroisonicotinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,6-dichloro-3-amino-4-pyridinecarboxylic acid methyl ester;
With
potassium hydroxide; ethanol; water;
at 20 ℃;
for 0.333333h;
With
hydrogenchloride; water;
In
ethanol;
at 20 ℃;
pH=~ 3;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tert-butyl alcohol / 24 h / 20 - 50 °C
2.1: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / diethyl ether; hexane / -78 - -10 °C
2.2: 0.5 h / -78 °C
2.3: pH ~ 3 / Acidic aqueous solution
3.1: hydrogenchloride; water / methanol / 2.5 h / Heating / reflux
3.2: 20 °C / pH ~ 14
3.3: pH ~ 3
4.1: methanol; diethyl ether; toluene / 2 h / 20 °C
5.1: N-chloro-succinimide / N,N-dimethyl-formamide / 15 h / 20 °C
6.1: potassium hydroxide; ethanol; water / 0.33 h / 20 °C
6.2: 20 °C / pH ~ 3
With
hydrogenchloride; potassium hydroxide; N-chloro-succinimide; n-butyllithium; ethanol; N,N,N,N,-tetramethylethylenediamine; water;
In
methanol; diethyl ether; hexane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: methanol; diethyl ether; toluene / 2 h / 20 °C
2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 15 h / 20 °C
3.1: potassium hydroxide; ethanol; water / 0.33 h / 20 °C
3.2: 20 °C / pH ~ 3
With
potassium hydroxide; N-chloro-succinimide; ethanol; water;
In
methanol; diethyl ether; N,N-dimethyl-formamide; toluene;
