2-(2-Methyl-1H-indol-1-YL)ethanamine

Base Information

• Chemical Name: 2-(2-Methyl-1H-indol-1-YL)ethanamine
• CAS No.: 883535-89-5
• Molecular Formula: C11H14N2
• Molecular Weight: 174.246
• Hs Code.: 2933990090
• European Community (EC) Number: 801-909-2
• DSSTox Substance ID: DTXSID20365921
• Wikidata: Q82150960
• Mol file: 883535-89-5.mol

Synonyms:2-(2-METHYL-1H-INDOL-1-YL)ETHANAMINE;883535-89-5;[2-(2-Methyl-1H-indol-1-yl)ethyl]amine;2-(2-methylindol-1-yl)ethanamine;2-(2-methyl-1H-indol-1-yl)ethan-1-amine;F1386-0300;SCHEMBL14334586;DTXSID20365921;PZTWBKQLMZMJDN-UHFFFAOYSA-N;BBL030266;STL243833;AKOS005208470;VS-09708;BB 0260220;EN300-237627;N16820;J-505662

Chemical Property of 2-(2-Methyl-1H-indol-1-YL)ethanamine

Chemical Property:

• Vapor Pressure: 0.00022mmHg at 25°C
• Boiling Point: 326.2°C at 760 mmHg
• Flash Point: 151.1°C
• PSA: 30.95000
• Density: 1.09g/cm³
• LogP: 2.60870
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 174.115698455
• Heavy Atom Count: 13
• Complexity: 170

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-methyl-1H-indol-1-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=CC=CC=C2N1CCN

Technology Process of 2-(2-Methyl-1H-indol-1-YL)ethanamine

There total 4 articles about 2-(2-Methyl-1H-indol-1-YL)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methyl-1H-indole (95-20-5) + 2-chloroethanamine hydrochloride (870-24-6) → 2-(2-methyl-1H-indol-1-yl)ethan-1-amine (883535-89-5)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In toluene; for 17h; Reflux; Inert atmosphere;

Reference yield: 99.0%

2-methyl-1H-indole (95-20-5) + 2-chloroethylamine hydrochloride → 2-(2-methyl-1H-indol-1-yl)ethan-1-amine (883535-89-5)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In toluene; for 17h; Reflux; Inert atmosphere;

Reference yield:

2-(2-methyl-1H-indol-1-yl)acetonitrile (104894-21-5) → 2-(2-methyl-1H-indol-1-yl)ethan-1-amine (883535-89-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm5000672

upstream raw materials:

2-(2-methyl-1H-indol-1-yl)acetonitrile

2-methyl-1H-indole

2-chloroethanamine hydrochloride

Downstream raw materials:

3-fluoro-N-(2-(2-methyl-1H-indol-1-yl)ethyl)-4-(4-methylpiperazin-1-yl)benzamide

(2E)-N-[2-(2-methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide

(E)-3-(4-methoxyphenyl)-N-(2-(2-methyl-1H-indol-1-yl)ethyl)acrylamide

N-(2-(2-methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)propanamide