1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID
• CAS No.: 886366-13-8
• Molecular Formula: C₁₁H₉F₃O₂
• Molecular Weight: 230.186
• Hs Code.: 2916399090
• Mol file: 886366-13-8.mol

Synonyms:1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Chemical Property of 1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.000202mmHg at 25°C
• Boiling Point: 314.1°C at 760 mmHg
• Flash Point: 143.7°C
• PSA: 37.30000
• Density: 1.424g/cm³
• LogP: 2.82160
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-(4-(Trifluoromethyl)phenyl)cyclopropanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID

There total 3 articles about 1-(4-TRIFLUOROMETHYL-PHENYL)-CYCLOPROPANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile (124276-61-5) → 1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid (886366-13-8)

Guidance literature:

With water; lithium hydroxide; at 100 ℃; for 15h;

DOI:10.1021/jm9013696

Reference yield:

4-(Trifluoromethyl)phenylacetonitrile (2338-75-2) → 1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid (886366-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 12 h / 50 °C

2: lithium hydroxide / water / 24 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; lithium hydroxide; In water;

DOI:10.1021/jacs.8b03509

Reference yield:

→ 1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carboxylic acid (886366-13-8)

Guidance literature:

upstream raw materials:

1-(4-(trifluoromethyl)phenyl)cyclopropane-1-carbonitrile

4-(Trifluoromethyl)phenylacetonitrile

Downstream raw materials:

2-hydroxy-(1-(1-(4-trifluoromethyl)phenyl)cyclopropyl)ethanone

Refernces

• 1、 -. "CARBOXY DERIVATIVES WITH ANTIINFLAMMATORY PROPERTIES". Page/Page column 119. . Retrieved 2021/07/02.
• 2、 Shi, Yongjia,Gao, Qian,Xu, Senmiao. "Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes". supporting information. p. 10599 - 10604. Retrieved 2019/08/28.