tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate

Base Information

• Chemical Name: tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate
• CAS No.: 1379322-06-1
• Molecular Formula: C9H18N2O3
• Molecular Weight: 202.25082
• Mol file: 1379322-06-1.mol

Synonyms:tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate;tert-Butyl N-[(3-aminooxetan-3-yl)methyl]carbamate;(3-Amino-oxetan-3-ylmethyl)-carbamic acid tert-butyl ester

Chemical Property of tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate

Chemical Property:

• PSA: 77.07000
• LogP: 1.14350
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Tert-Butyl((3-Aminooxetan-3-Yl)Methyl)Carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate

There total 4 articles about tert-Butyl ((3-aMinooxetan-3-yl)Methyl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl ((3-(benzylamino)oxetan-3-yl)methyl)carbamate → (3-amino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester (1379322-06-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 22h;

DOI:10.1021/acs.orglett.7b00745

Reference yield: 90.0%

(3-dibenzylamino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester (1422496-53-4) → (3-amino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester (1379322-06-1)

Guidance literature:

With 10 wt% Pd(OH)2 on carbon; hydrogen; In ethanol;

Reference yield:

tert-butyl ((3-(N-benzyl-4-methylphenylsulfonamido)oxetan-3-yl)methyl)-carbamate → (3-amino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester (1379322-06-1)

Guidance literature:

Multi-step reaction with 2 steps

1: magnesium / methanol; tetrahydrofuran / 6 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 22 h

With palladium 10% on activated carbon; hydrogen; magnesium; In tetrahydrofuran; methanol;

DOI:10.1021/acs.orglett.7b00745

upstream raw materials:

(3-dibenzylamino-oxetan-3-ylmethyl)carbamic acid tert-butyl ester

di-tert-butyl dicarbonate