AZD9496

Base Information

Chemical Name:AZD9496
CAS No.:1639042-08-2
Molecular Formula:C25H25F3N2O2
Molecular Weight:442.47
Hs Code.:
Mol file:1639042-08-2.mol

Synonyms:AZD9496;(E)-3-[3,5-Difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]phenyl]acrylic acid

Suppliers and Price of AZD9496

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
AZD9496 >98%
100 mg
$ 850.00

Crysdot
AZD9496 98+%
10mg
$ 190.00

Crysdot
AZD9496 98+%
5mg
$ 115.00

Crysdot
AZD9496 98+%
50mg
$ 620.00

Crysdot
AZD9496 98+%
25mg
$ 380.00

Cayman Chemical
AZD 9496 ≥98%
10mg
$ 280.00

Cayman Chemical
AZD 9496 ≥98%
25mg
$ 525.00

Cayman Chemical
AZD 9496 ≥98%
1mg
$ 35.00

Cayman Chemical
AZD 9496 ≥98%
5mg
$ 158.00

Biosynth Carbosynth
AZD 9496
10 mg
$ 125.00

Total 24 raw suppliers

Chemical Property of AZD9496

Chemical Property:

Boiling Point:541.0±50.0 °C(Predicted)
PKA:4.08±0.10(Predicted)
PSA：56.33000
Density:1.286±0.06 g/cm3(Predicted)
LogP:5.56590
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

AZD9496 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description AZD 9496 is a potent and selective estrogen receptor downregulator (SERD) with an IC50 value of 0.138 nM for estrogen receptor α (ERα) downregulation. It is selective for ERα compared to other nuclear hormone receptors with IC50 values of 0.0008, 0.54, 9.2, and 30 μM for ERα, progesterone receptor (PR), glucocorticoid receptor (GR), and androgen receptor (AR), respectively. AZD 9496 decreases ERα activity (IC50 = 0.282 nM), measured via quantification of downstream PR activity, and reduces proliferation of MCF-7 breast cancer cells (IC50 = 0.0398 nM). It also inhibits MCF-7 xenograft growth in mice in a dose-dependent manner. AZD 9496 is orally bioavailable and formulations containing it are under investigation in clinical trials for treatment of ER positive breast cancer.

Technology Process of AZD9496

There total 7 articles about AZD9496 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (E)-methyl 3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylate

: 1639042-08-2
(E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl-propyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

Guidance literature:: (E)-methyl 3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylate; With water; sodium hydroxide; In isopropyl alcohol; at 21 ℃; for 16h; Inert atmosphere; Darkness;

With hydrogenchloride; In water; at 50 - 53 ℃; for 1h; Time; Temperature; Solvent;

Reference yield:

: 7795-52-0,304-54-1
(-)-alpha-Methyltryptamine

: 1639042-08-2
(E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl-propyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 70 °C / Inert atmosphere; Large scale

2.1: acetic acid / toluene / 5 h / 80 °C

3.1: sodium hydroxide; water / isopropyl alcohol / 16 h / 21 °C / Inert atmosphere; Darkness

3.2: 1 h / 50 - 53 °C

With water; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; isopropyl alcohol; toluene;

Reference yield:

: 537013-51-7
4-bromo-2,6-difluorobenzaldehyde

: 1639042-08-2
(E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methyl-propyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl acetamide / 6 h / 80 °C

2.1: acetic acid / toluene / 5 h / 80 °C

3.1: sodium hydroxide; water / isopropyl alcohol / 16 h / 21 °C / Inert atmosphere; Darkness

3.2: 1 h / 50 - 53 °C

With water; palladium diacetate; acetic acid; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; In N,N-dimethyl acetamide; isopropyl alcohol; toluene;