Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate

Base Information

• Chemical Name: Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate
• CAS No.: 33288-74-3
• Molecular Formula: C₁₆H₁₈N₄O₅S
• Molecular Weight: 378.409
• European Community (EC) Number: 642-309-9
• UNII: 6R8ZR7LT5L
• DSSTox Substance ID: DTXSID60186915
• Wikidata: Q27265377
• Mol file: 33288-74-3.mol

Synonyms:33288-74-3;Glipizide EP Impurity G;Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate;6R8ZR7LT5L;N-[4-[beta-(5-Methylpyrazine-2-carboxaMido)ethyl]phenylsulfonyl]Methylurethane;METHYL 4-[BETA-(5-METHYLPYRAZINE-2-CARBOXAMIDO)ETHYL]BENZENE SULFONAMIDE CARBAMATE;methyl N-[4-[2-[(5-methylpyrazine-2-carbonyl)amino]ethyl]phenyl]sulfonylcarbamate;Methyl [[4-[2-[[(5-Methylpyrazin-2-yl)carbonyl]amino]ethyl]phenyl]sulphonyl]carbamate;UNII-6R8ZR7LT5L;Glipizide Imp. G (EP);Glipizide Impurity G;GlipizideEPImpurityG;DTXSID60186915;Methyl 4-[|A-(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate;N-[[4-[2-[[(5-Methyl-2-pyrazinyl)carbonyl]amino]ethyl]phenyl]sulfonyl]carbamic Acid Methyl Ester;GLIPIZIDE IMPURITY G [EP IMPURITY];EN300-20053306;J-019131;Q27265377;Z3177425065;Methyl 4-[ beta -(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate;Methyl 4-[b-(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate;METHYL N-(4-{2-[(5-METHYLPYRAZIN-2-YL)FORMAMIDO]ETHYL}BENZENESULFONYL)CARBAMATE;N-(4-(.BETA.-(5-METHYLPYRAZINE-2-CARBOXAMIDO)ETHYL)PHENYLSULFONYL)METHYLURETHANE;CARBAMIC ACID, ((4-(2-(((5-METHYLPYRAZINYL)CARBONYL)AMINO)ETHYL)PHENYL)SULFONYL)-, METHYL ESTER;CARBAMIC ACID, ((P-(2-(5-METHYLPYRAZINECARBOXAMIDO)ETHYL)PHENYL)SULFONYL)-, METHYL ESTER;CARBAMIC ACID, N-((4-(2-(((5-METHYL-2-PYRAZINYL)CARBONYL)AMINO)ETHYL)PHENYL)SULFONYL)-, METHYL ESTER

Chemical Property of Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate

Chemical Property:

• PKA: 4?+-.0.10(Predicted)
• PSA: 142.71000
• Density: 1.350±0.06 g/cm3(Predicted)
• LogP: 2.66220
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 378.09979086
• Heavy Atom Count: 26
• Complexity: 584

Purity/Quality:

98% ^*data from raw suppliers

Methyl4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzeneSulfonamideCarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)OC
• Uses: Methyl 4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate is an intermediate in the synthesis of Glipizide (G410225). Methyl 4-[β-(5-Methylpyrazine-2-carboxamido)ethyl]benzene Sulfonamide Carbamate (Glipizide EP Impurity G) is an intermediate in the synthesis of Glipizide (G410225).

Technology Process of Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate

There total 1 articles about Methyl ((4-(2-(((5-methylpyrazin-2-yl)carbonyl)amino)ethyl)phenyl)sulfonyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ {4-[2-(5-methyl-pyrazine-2-carbonylamino)-ethyl]-benzenesulfonyl}-carbamic acid methyl ester (33288-74-3)

Guidance literature:

entspr. Sulfonamid, K2CO3, ClCOOCH3;

Refernces