BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER

Base Information

Chemical Name:BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER
CAS No.:358749-82-3
Molecular Formula:C₁₉H₂₁NO₄S
Molecular Weight:359.446
Hs Code.:
Mol file:358749-82-3.mol

Synonyms:BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER

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Chemical Property of BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER

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Technology Process of BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER

There total 1 articles about BENZO[B]THIOPHENE-6-CARBOXYLIC ACID, 2-AMINO-4,5,6,7-TETRAHYDRO-3-(4-METHOXYBENZOYL)-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 3672-47-7
3-oxo-3-(4'-methoxyphenyl)propanenitrile

: 358749-82-3
2-amino-4,5,6,7-tetrahydro-3-(4-methoxybenzoyl)-1-benzothiophene-6-carboxylic acid ethyl ester

Guidance literature:: With morpholine; sulfur; In ethanol; for 3h; Heating / reflux;

Reference yield:

: 358749-82-3
2-amino-4,5,6,7-tetrahydro-3-(4-methoxybenzoyl)-1-benzothiophene-6-carboxylic acid ethyl ester

: 869899-79-6
(7S)-3-chloro-2-[(2,4-dioxo-1,3-oxazolidin-3-yl)methyl]-5,6,7,8-tetrahydro-4-(4-methoxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: aluminum (III) chloride / tetrahydrofuran / 1.58 h / 0 °C / Heating / reflux

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 80 °C

3: hydrogenchloride; water / 1,4-dioxane / 3.5 h / 80 °C

4: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

5: Resolution of racemate

With hydrogenchloride; N-hydroxybenzotriazole ammonium salt; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; aluminum (III) chloride; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide);

Reference yield:

: 358749-82-3
2-amino-4,5,6,7-tetrahydro-3-(4-methoxybenzoyl)-1-benzothiophene-6-carboxylic acid ethyl ester

: (7S)-3-chloro-2-[(2,4-dioxo-1,3-oxazolidin-3-yl)methyl]-5,6,7,8-tetrahydro-4-(4-hydroxyphenyl) [1]benzothieno[2,3-b]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / tetrahydrofuran / 1.58 h / 0 °C / Heating / reflux

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 2 h / 80 °C

3: hydrogenchloride; water / 1,4-dioxane / 3.5 h / 80 °C

4: N-hydroxybenzotriazole ammonium salt; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

5: Resolution of racemate

6: methanesulfonic acid; DL-methionine / 3 h / 80 °C

With hydrogenchloride; N-hydroxybenzotriazole ammonium salt; methanesulfonic acid; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; DL-methionine; aluminum (III) chloride; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide);