1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: 1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester
• CAS No.: 886449-72-5
• Molecular Formula: C13H22N2O3
• Molecular Weight: 254.32538
• Hs Code.: 2933990090
• Mol file: 886449-72-5.mol

Synonyms:1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester;1-N-Boc-1,7-diaza-spiro[4,5]decan-6-one;tert-Butyl 10-oxo-4,9-diazaspiro[4.5]decane-4-carboxylate

Chemical Property of 1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester

Chemical Property:

• Vapor Pressure: 1.05E-07mmHg at 25°C
• Boiling Point: 433.2°C at 760 mmHg
• Flash Point: 215.8°C
• PSA: 58.64000
• Density: 1.11g/cm³
• LogP: 1.93280
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 10-oxo-4,9-diazaspiro[4.5]decane-4-carboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester

There total 4 articles about 1,7-Diazaspiro[4.5]decane-1-carboxylic acid, 6-oxo-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S)-pyrrolidine carboxylate (2577-48-2) → 6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester (886449-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 74 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

2.1: LiHMDS / tetrahydrofuran

2.2: potassium carbonate / methanol

3.1: toluene / Heating

With dmap; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2006.03.021

Reference yield:

(S)-N-(tert-butoxycarbonyl)proline methyl ester (59936-29-7) → 6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester (886449-72-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LiHMDS / tetrahydrofuran

1.2: potassium carbonate / methanol

2.1: toluene / Heating

With lithium hexamethyldisilazane; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetlet.2006.03.021

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → 6-oxo-1,7-diaza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester (886449-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 94 percent / SOCl₂ / Heating

2.1: 74 percent / DMAP; Et₃N / CH₂Cl₂ / 20 °C

3.1: LiHMDS / tetrahydrofuran

3.2: potassium carbonate / methanol

4.1: toluene / Heating

With dmap; thionyl chloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.tetlet.2006.03.021

upstream raw materials:

methyl (2S)-pyrrolidine carboxylate

(S)-N-(tert-butoxycarbonyl)proline methyl ester

L-proline

Downstream raw materials:

7-benzyl-6-oxo-1,7-diazaspiro[4.5]decane-1-carboxylic acid tert-butyl ester

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