2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI)

Base Information

• Chemical Name: 2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI)
• CAS No.: 206123-70-8
• Molecular Formula: C10H18O2
• Molecular Weight: 170.25
• Mol file: 206123-70-8.mol

Synonyms:2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI)

Chemical Property of 2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI)

Chemical Property:

• PSA: 26.30000
• LogP: 2.23010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI)

There total 96 articles about 2H-Pyran-2-one,tetrahydro-3,5-dimethyl-6-(1-methylethyl)-,(3R,5R,6R)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,4R,5S)-2,4,6-Trimethylheptane-1,5-diol → (3S,5R,6S)-3,5-dimethyl-6-isopropyl-3,4,5,6-tetrahydropyran-2-one (206123-70-8,648434-47-3)

Guidance literature:

With 4-methylmorpholine N-oxide; tris(triphenylphosphine)ruthenium(II) chloride; In acetone; for 5h; Ambient temperature;

DOI:10.1021/jo00062a048

Reference yield: 99.0%

(2R,4S,5R)-2,4,6-Trimethylheptane-1,5-diol (147753-94-4) → (3R,5S,6R)-3,5-Dimethyl-6-(methylethyl)-3,4,5,6-tetrahydropyran-2-one (206123-70-8,648434-47-3)

Guidance literature:

With 4-methylmorpholine N-oxide; tris(triphenylphosphine)ruthenium(II) chloride; In acetone; for 5h; Ambient temperature;

DOI:10.1021/jo00062a048

Reference yield: 98.0%

(3S,6S)-tetrahydro-6-isopropyl-3-methyl-5-methylenepyran-2-one (1338955-14-8) → (3S,5S,6S)-tetrahydro-6-isopropyl-3,5-dimethylpyran-2-one (1338955-10-4,206123-70-8,648434-47-3)

Guidance literature:

With Wilkinson's catalyst; hydrogen; In benzene; at 20 ℃; for 3h; under 750.075 Torr; diastereoselective reaction;

DOI:10.1016/j.tetasy.2011.08.005

upstream raw materials:

(2R,4S,5R)-2,4,6-Trimethylheptane-1,5-diol

(2R)-2,4-Dimethylpent-4-en-1-ol

(2R)-1-<(tert-Butyldimethylsilyl)oxy>-2,4-dimethylpent-4-ene

(2S,4R)-5-(tert-butyl(dimethyl)silyloxy)-2,4-dimethyl-1-pentanol