[1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol

Base Information

Chemical Name:[1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol
CAS No.:309938-27-0
Molecular Formula:C₁₅H₁₃FN₂O
Molecular Weight:256.279
Hs Code.:
European Community (EC) Number:808-769-1
DSSTox Substance ID:DTXSID20354017
Wikidata:Q82131938
ChEMBL ID:CHEMBL601956
Mol file:309938-27-0.mol

Synonyms:309938-27-0;[1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol;[1-[(2-fluorophenyl)methyl]benzimidazol-2-yl]methanol;{1-[(2-fluorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}methanol;GNF-Pf-391;CHEMBRDG-BB 6281686;MFCD01630004;(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methanol;CBMicro_047818;Cambridge id 6281686;Oprea1_261391;Oprea1_310446;CHEMBL601956;F0850-2327;DTXSID20354017;STK050137;AKOS000274626;CCG-142669;BS-37479;BIM-0047794.P001;BB 0219487;EN300-40328;AB00104982-01;SR-01000439597;J-018219;SR-01000439597-1;[1-(2-Fluorobenzyl)-1H-benzoimidazol-2-yl]methanol;Z25755075

Suppliers and Price of [1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of [1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol

Chemical Property:

Vapor Pressure:1.75E-09mmHg at 25°C
Boiling Point:466°C at 760 mmHg
Flash Point:235.6°C
Density:1.25g/cm³
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:256.10119120
Heavy Atom Count:19
Complexity:302

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CN2C3=CC=CC=C3N=C2CO)F

Technology Process of [1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol

There total 3 articles about [1-(2-fluorobenzyl)-1H-benzimidazol-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 446-48-0
o-fluorobenzyl bromide

: 4856-97-7
2-(Hydroxymethyl)benzimidazole

: 309938-27-0
(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methanol

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1039/c8md00278a

Reference yield: 70.0%

: 4856-97-7
2-(Hydroxymethyl)benzimidazole

: 309938-27-0
(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methanol

Guidance literature:: 2-(Hydroxymethyl)benzimidazole; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 0.333333h;

(2-fluorobenzyl) halide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2021.116352

Reference yield:

: 95-54-5
1,2-diamino-benzene

: 309938-27-0
(1-(2-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 6 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

With hydrogenchloride; potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1039/c8md00278a