O6-Benzyl-N2,3-etheno Guanosine

Base Information

• Chemical Name: O6-Benzyl-N2,3-etheno Guanosine
• CAS No.: 108060-84-0
• Molecular Formula: C19H19N5O5
• Molecular Weight: 399
• Mol file: 108060-84-0.mol

Synonyms:O6-Benzyl-N2,3-etheno Guanosine;4-(PhenylMethoxy)-1-β-D-ribofuranosyl-1H-iMidazo[2,1-b]purine

Chemical Property of O6-Benzyl-N2,3-etheno Guanosine

Chemical Property:

• PSA: 127.16000
• LogP: 0.26950

Purity/Quality:

97% ^*data from raw suppliers

O6-Benzyl-N2,3-etheno guanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of fluorescent Guanosine nucleotide analogs.

Technology Process of O6-Benzyl-N2,3-etheno Guanosine

There total 7 articles about O6-Benzyl-N2,3-etheno Guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.9%

2-amino-6-benzyloxy-9-β-D-ribofuranosylpurine (4552-61-8) + bromoacetaldehyde (17157-48-1) → (2R,3R,4S,5R)-2-(4-(benzyloxy)-1H-imidazo[2,1-b]purin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (108060-84-0)

Guidance literature:

With sodium acetate; acetic acid; potassium iodide; In ethanol; water; at 37 - 40 ℃; for 30h; pH=4.5;

DOI:10.1021/jo00061a033

Reference yield:

N2-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine (70337-80-3) → (2R,3R,4S,5R)-2-(4-(benzyloxy)-1H-imidazo[2,1-b]purin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (108060-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 48.3 percent / triphenylphosphine, diethyl azodicarboxylate / dioxane / 48 h / 24 °C

2: 93 percent / NaOH / methanol / 48 h / Ambient temperature

3: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H₂O / 30 h / 37 - 40 °C / pH=4.5

With sodium hydroxide; sodium acetate; acetic acid; triphenylphosphine; potassium iodide; diethylazodicarboxylate; In 1,4-dioxane; methanol; ethanol; water;

DOI:10.1021/jo00061a033

Reference yield:

O6-benzyl-N2,2',3',5'-tetraisobutyrylguanosine (148437-88-1) → (2R,3R,4S,5R)-2-(4-(benzyloxy)-1H-imidazo[2,1-b]purin-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (108060-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / NaOH / methanol / 48 h / Ambient temperature

2: 47.9 percent / aq. sodium acetate, aq. acetic acid, KI / ethanol; H₂O / 30 h / 37 - 40 °C / pH=4.5

With sodium hydroxide; sodium acetate; acetic acid; potassium iodide; In methanol; ethanol; water;

DOI:10.1021/jo00061a033

upstream raw materials:

2-amino-6-benzyloxy-9-β-D-ribofuranosylpurine

bromoacetaldehyde

N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine

O⁶-benzyl-N²,2',3',5'-tetraisobutyrylguanosine

Downstream raw materials:

O⁶-Benzyl-N²,3-etheno-2'-O--3',5'-O-(1,1,3,3-tetraisopropyldisiloxa-1,3-diyl)guanosine

O⁶-Benzyl-N²,3-etheno-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxa-1,3-diyl)guanosine

O⁶-Benzyl-N²,3-etheno-2'-deoxyguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 108060-84-0 O6-Benzyl-N2,3-etheno Guanosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send