3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene

Base Information

Chemical Name:3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene
CAS No.:528604-88-8
Molecular Formula:C14H12Cl2S3
Molecular Weight:347.353
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10458533
Nikkaji Number:J1.909.530D
Wikidata:Q72465976
Mol file:528604-88-8.mol

Synonyms:528604-88-8;3,4-BIS(5-CHLORO-2-METHYLTHIOPHEN-3-YL)-2,5-DIHYDROTHIOPHENE;DTXSID10458533;3,4-Bis(2-methyl-5-chloro-3-thienyl)-2,5-dihydrothiophene;1~5~,3~5~-Dichloro-1~2~,3~2~-dimethyl-2~2~,2~5~-dihydro-1~3~,2~3~:2~4~,3~3~-terthiophene

Suppliers and Price of 3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3,4-BIS-(5-CHLORO-2-METHYLTHIOPHEN-3-YL)-2,5-DIHYDROTHIOPHENE 95.00%
5MG
$ 501.44

Total 2 raw suppliers

Chemical Property of 3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene

Chemical Property:

Boiling Point:477.6±45.0 °C(Predicted)
PSA：81.78000
Density:1.439±0.06 g/cm3(Predicted)
LogP:6.39080
XLogP3:5.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:345.9478193
Heavy Atom Count:19
Complexity:351

Purity/Quality:

99% ^*data from raw suppliers

3,4-BIS-(5-CHLORO-2-METHYLTHIOPHEN-3-YL)-2,5-DIHYDROTHIOPHENE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=C(S1)Cl)C2=C(CSC2)C3=C(SC(=C3)Cl)C

Technology Process of 3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene

There total 1 articles about 3,4-Bis(5-chloro-2-methylthiophen-3-YL)-2,5-dihydrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17249-82-0
2-chloro-5-methylthiophene

: 528604-88-8
3,4-bis-[2,2'-dimethyl-5,5'-(dichlorodithienyl)]-2,5-dihydrothiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / CH₂Cl₂ / 0.5 h / 0 °C

1.2: 78 percent / CH₂Cl₂ / 9 h / 0 - 20 °C

2.1: 53 percent / Br₂ / CHCl₃ / 12 h

3.1: 65 percent / Na₂S / ethanol / 1 h / 20 °C

4.1: 70 percent / TiCl₄; Zn powder / tetrahydrofuran / 48 h / 20 °C

With sodium sulfide; aluminium trichloride; bromine; titanium tetrachloride; zinc; In tetrahydrofuran; ethanol; dichloromethane; chloroform; 4.1: McMurry coupling;
DOI:10.1021/ol034166r

Reference yield:

: 528604-88-8
3,4-bis-[2,2'-dimethyl-5,5'-(dichlorodithienyl)]-2,5-dihydrothiophene

: 888743-92-8
5,5''-bis-(4-methoxy-phenyl)-2,2''-dimethyl-2',5'-dihydro-[3,3';4',3'']terthiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C

1.2: 63 percent / I₂ / tetrahydrofuran; hexane / -78 - -20 °C

2.1: K₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 0.17 h / 20 °C

2.2: 84 percent / tetrahydrofuran / Heating

With n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; 2.1: Suzuki coupling;
DOI:10.1055/s-2006-933108

Reference yield:

: 528604-88-8
3,4-bis-[2,2'-dimethyl-5,5'-(dichlorodithienyl)]-2,5-dihydrothiophene

: 2,2''-dimethyl-5,5''-bis-(3-nitro-phenyl)-2',5'-dihydro-[3,3';4',3'']terthiophene

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -50 °C

1.2: 63 percent / I₂ / tetrahydrofuran; hexane / -78 - -20 °C

2.1: K₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 0.17 h / 20 °C

2.2: 88 percent / tetrahydrofuran / Heating

With n-butyllithium; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; 2.1: Suzuki coupling;
DOI:10.1055/s-2006-933108