4-Chloro-2-iodo-5-(trifluoromethyl)aniline

Base Information

• Chemical Name: 4-Chloro-2-iodo-5-(trifluoromethyl)aniline
• CAS No.: 852569-36-9
• Molecular Formula: C7H4ClF3IN
• Molecular Weight: 321.4660396
• Hs Code.: 2928009090
• Mol file: 852569-36-9.mol

Synonyms:4-Chloro-2-iodo-5-(trifluoromethyl)aniline;5-Amino-2-chloro-4-iodobenzotrifluoride;4-Chloro-2-iodo-5-trifluoromethyl-phenylamine

Chemical Property of 4-Chloro-2-iodo-5-(trifluoromethyl)aniline

Chemical Property:

• Boiling Point: 290.6±40.0 °C(Predicted)
• PKA: 0.68±0.10(Predicted)
• PSA: 26.02000
• Density: 2.018±0.06 g/cm3(Predicted)
• LogP: 4.12680

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-2-chloro-4-iodobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-iodo-5-(trifluoromethyl)aniline

There total 1 articles about 4-Chloro-2-iodo-5-(trifluoromethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-3-trifluoromethyl-aniline (320-51-4) → 4-chloro-2-iodo-5-(trifluoromethyl)aniline (852569-36-9)

Guidance literature:

With N-iodo-succinimide; In tetrahydrofuran; methanol;

DOI:10.1021/ol050623n

Reference yield:

4-chloro-2-iodo-5-(trifluoromethyl)aniline (852569-36-9) + 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (865245-32-5) + methyl 3-(chlorosulfonyl)-4-cyclopropylbenzoate → methyl 3-(N-(4-chloro-2-(piperidin-2-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)-4-cyclopropylbenzoate

Guidance literature:

4-chloro-2-iodo-5-(trifluoromethyl)aniline; 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 80 ℃; for 4h; Inert atmosphere;

methyl 3-(chlorosulfonyl)-4-cyclopropylbenzoate; With pyridine; at 20 ℃; for 72h; Further stages;

Reference yield:

4-chloro-2-iodo-5-(trifluoromethyl)aniline (852569-36-9) → N-(4-chloro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide (868692-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / Heating

2: aq. NaOH / methanol

With pyridine; sodium hydroxide; In methanol;

DOI:10.1016/j.bmcl.2006.08.036

upstream raw materials:

4-chloro-3-trifluoromethyl-aniline

Downstream raw materials:

N-(4-chloro-2-iodo-5-trifluoromethyl-phenyl)-methanesulfonamide

2-(5-chloro-6-trifluoromethyl-1H-indol-2-yl)-1-(4-fluoro-phenylsulfanyl)-propan-2-ol

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