Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)

Base Information

• Chemical Name: Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)
• CAS No.: 166115-75-9
• Molecular Formula: C18H25N4O6P
• Molecular Weight: 424.39
• Mol file: 166115-75-9.mol

Synonyms:Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)

Chemical Property of Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)

Chemical Property:

• Melting Point: 184 °C (dimethylformamide)
• PSA: 144.46000
• LogP: 2.33880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)

There total 2 articles about Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4,5-Diamino-1,3-dimethyluracil (5440-00-6) + 4-[(diethoxyphosphoryl)-methyl]benzoyl chloride (118578-91-9) → [4-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (166115-75-9)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; for 12h; Ambient temperature;

DOI:10.1016/0223-5234(96)88233-X

Reference yield:

4-[(diethoxyphosphinyl)methyl]benzoic acid (28149-48-6) → [4-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (166115-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / thionyl chloride / cyclohexane / 4 h / Heating

2: 70 percent / pyridine / dimethylformamide / 12 h / Ambient temperature

With pyridine; thionyl chloride; In cyclohexane; N,N-dimethyl-formamide;

DOI:10.1016/0223-5234(96)88233-X

Reference yield: 44.0%

[4-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (166115-75-9) → [4-(1,3-Dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-benzyl]-phosphonic acid diethyl ester

Guidance literature:

With aluminium trichloride; phosphorus pentoxide; In pyridine; for 4h; Heating;

DOI:10.1016/0223-5234(96)88233-X

upstream raw materials:

4,5-Diamino-1,3-dimethyluracil

4-[(diethoxyphosphoryl)-methyl]benzoyl chloride

4-[(diethoxyphosphinyl)methyl]benzoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 166115-75-9 Phosphonic acid, [[4-[[(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)amino]carbonyl]phenyl]methyl]-, diethyl ester (9CI)

Send

Send

Metric Ton KG G Pound L ML

Send

Send