5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]-

Base Information

• Chemical Name: 5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]-
• CAS No.: 1095825-46-9
• Molecular Formula: C12H7ClF3N3O2S
• Molecular Weight: 349.721
• Hs Code.: 2934100090
• Mol file: 1095825-46-9.mol

Synonyms:5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]-

Chemical Property of 5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]-

Chemical Property:

• PSA: 103.68000
• LogP: 4.04920
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

2-Acetyl-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]-

There total 3 articles about 5-ThiazolecarboxaMide, 2-acetyl-N-[5-chloro-4-(trifluoroMethyl)-2-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-acetyl-1,3-thiazole-5-carboxylic acid (1095824-76-2) + 5-chloro-4-(trifluoromethyl)pyridin-2-amine hydrochloride (1095824-77-3) → 2-acetyl-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide (1095825-46-9)

Guidance literature:

2-acetyl-1,3-thiazole-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; at 10 - 35 ℃; for 2h;

5-chloro-4-(trifluoromethyl)pyridin-2-amine hydrochloride; With pyridine; In acetonitrile; at 5 - 50 ℃; for 2h;

Reference yield:

5-chloro-4-(trifluoromethyl)pyridin-2-amine hydrochloride (1095824-77-3) + C6H4ClNO2S → 2-acetyl-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide (1095825-46-9)

Guidance literature:

With pyridine; In acetonitrile; at 5 - 20 ℃; for 20h; Inert atmosphere;

Reference yield:

2-acetyl-1,3-thiazole-5-carboxylic acid (1095824-76-2) → 2-acetyl-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide (1095825-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / 1,2-dimethoxyethane / 3.25 h / 20 °C / Inert atmosphere

2: pyridine / acetonitrile / 20 h / 5 - 20 °C / Inert atmosphere

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; acetonitrile;

upstream raw materials:

2-acetyl-1,3-thiazole-5-carboxylic acid

5-chloro-4-(trifluoromethyl)pyridin-2-amine hydrochloride

Downstream raw materials:

C₁₂H₈ClF₃N₄O₂S

2-(1-aminoethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxamide

2-((1R)-1-aminoethyl)-N-(5-chloro-4-(trifluoromethyl)pyridin-2-yl)-1,3-thiazole-5-carboxamide

C₁₂H₁₀ClF₃N₄OS

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