5-Pyrid-2-ylthiophene-2-sulfonamide

Base Information

• Chemical Name: 5-Pyrid-2-ylthiophene-2-sulfonamide
• CAS No.: 190659-63-3
• Molecular Formula: C9H8N2O2S2
• Molecular Weight: 240.3
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID101284341
• Nikkaji Number: J1.500.385E
• ChEMBL ID: CHEMBL332559
• Mol file: 190659-63-3.mol

Synonyms:5-Pyrid-2-ylthiophene-2-sulfonamide;190659-63-3;5-pyridin-2-ylthiophene-2-sulfonamide;5-(pyridin-2-yl)thiophene-2-sulfonamide;5-Pyridin-2-yl-thiophene-2-sulfonic acid amide;5-(2-pyridyl)thiophene-2-sulfonamide;LeadQuest Compound 5;CHEMBL332559;SCHEMBL4109831;BDBM13071;DTXSID101284341;MFCD00107905;AKOS015996763;AS-5661;5-(2-pyridinyl)-2-thiophenesulfonamide;CS-0316378;5-Pyridin-2-ylthiophene-2-sulfonic acid amide;EN300-9457883

Chemical Property of 5-Pyrid-2-ylthiophene-2-sulfonamide

Chemical Property:

• PSA: 109.67000
• LogP: 3.23860
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 240.00271985
• Heavy Atom Count: 15
• Complexity: 313

Purity/Quality:

98% ^*data from raw suppliers

5-Pyridin-2-ylthiophene-2-sulfonic acid amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C2=CC=C(S2)S(=O)(=O)N

Technology Process of 5-Pyrid-2-ylthiophene-2-sulfonamide

There total 1 articles about 5-Pyrid-2-ylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

5-pyridin-2-yl-thiophene-2-sulfonyl chloride (151858-64-9) → 5-(pyridin-2-yl)-thiophene-2-sulfonamide (190659-63-3)

Guidance literature:

With ammonia; In dichloromethane; at -78 ℃; for 4h;

DOI:10.1021/jm9607818

Reference yield:

5-(pyridin-2-yl)-thiophene-2-sulfonamide (190659-63-3) → 5-Pyridin-2-yl-thiophene-2-sulfonic acid 1-amino-1-(4-chloro-phenylamino)-meth-(E)-ylideneamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. NaOH

2: 6.5 percent / NH₂OH*HCl, Et₃N / CHCl₃ / 48 h / Heating

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; In chloroform;

DOI:10.1021/jm9607818

Reference yield:

5-(pyridin-2-yl)-thiophene-2-sulfonamide (190659-63-3) → 5-Pyridin-2-yl-thiophene-2-sulfonic acid 1-(4-chloro-phenylamino)-1-hydroxyamino-meth-(Z)-ylideneamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. NaOH

2: 52.2 percent / NH₂OH*HCl, Et₃N / CHCl₃ / 48 h / Heating

With sodium hydroxide; hydroxylamine hydrochloride; triethylamine; In chloroform;

DOI:10.1021/jm9607818

upstream raw materials:

5-pyridin-2-yl-thiophene-2-sulfonyl chloride