N-Me-D-His-OMe·HCl

Base Information

• Chemical Name: N-Me-D-His-OMe·HCl
• CAS No.: 1219090-51-3
• Molecular Formula: C8H13N3O2·HCl
• Molecular Weight: 183.21
• Mol file: 1219090-51-3.mol

Synonyms:N-Me-D-His-OMe·HCl

Chemical Property of N-Me-D-His-OMe·HCl

Chemical Property:

Purity/Quality:

HPLC>98% ^*data from raw suppliers

N-Me-D-His-OMe?HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Me-D-His-OMe·HCl

There total 4 articles about N-Me-D-His-OMe·HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-benzyl-N-methyl-L-histidine methyl ester (866392-18-9) → N-methyl-L-hystidine methyl ester (1219090-51-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 18h; under 2844.31 Torr;

DOI:10.1021/ol051441w

Reference yield:

(S)-3-(3H-Imidazol-4-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester (78640-70-7) → N-methyl-L-hystidine methyl ester (1219090-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaBH₃CN / methanol / 18 h / 20 °C

2.1: methanol / 5 h / 20 °C

2.2: 554 mg / NaBH₃CN / methanol / 18 h / 20 °C

3.1: 99 percent / H₂ / Pd(OH)2 / methanol / 18 h / 2844.31 Torr

With hydrogen; sodium cyanoborohydride; palladium dihydroxide; In methanol;

DOI:10.1021/ol051441w

Reference yield:

2-benzylamino-3-(3H-imidazol-4-yl)-propionic acid methyl ester (69937-81-1) → N-methyl-L-hystidine methyl ester (1219090-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 5 h / 20 °C

1.2: 554 mg / NaBH₃CN / methanol / 18 h / 20 °C

2.1: 99 percent / H₂ / Pd(OH)2 / methanol / 18 h / 2844.31 Torr

With hydrogen; palladium dihydroxide; In methanol;

DOI:10.1021/ol051441w

upstream raw materials:

N-benzyl-N-methyl-L-histidine methyl ester

(S)-3-(3H-Imidazol-4-yl)-2-{[1-phenyl-meth-(E)-ylidene]-amino}-propionic acid methyl ester

2-benzylamino-3-(3H-imidazol-4-yl)-propionic acid methyl ester

L-histidine methyl ester

Refernces