1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE

Base Information

• Chemical Name: 1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE
• CAS No.: 161709-56-4
• Molecular Formula: C27H29N3O4S
• Molecular Weight: 491.6
• Mol file: 161709-56-4.mol

Synonyms:NAPSUL-ILE-TRP-CHO;N-(1-NAPHTHALENYLSULFONYL)-ILE-TRP-ALDEHYDE;1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE;1-NAPTHALENESULFONYL-ILE-TRP-ALDEHYDE

Chemical Property of 1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE

Chemical Property:

• PSA: 116.51000
• LogP: 5.80310
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-(1-Naphthalenylsulfonyl)-Ile-Trp-aldehyde is an inhibitor of cathepsin L.

Technology Process of 1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE

There total 15 articles about 1-NAPHTHALENYLSULFONYL-ILE-TRP-ALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2S,3S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-2-(1H-indol-3-yl)-1-(methoxy-methyl-carbamoyl)-ethyl]-amide (182216-60-0) → 1-napthalenesulfonyl-Ile-Trp-CHO (161709-56-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -50 ℃; for 4h;

DOI:10.1021/jm9803065

Reference yield: 58.0%

→ NapSul-Ile-Trp-CHO (161709-56-4)

Guidance literature:

Reference yield: 50.0%

(2S,3S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethyl]-amide (161708-63-0) → 1-napthalenesulfonyl-Ile-Trp-CHO (161709-56-4)

Guidance literature:

With pyridine-SO₃ complex; dimethyl sulfoxide; triethylamine; for 0.833333h; Ambient temperature;

DOI:10.1021/jm9803065

upstream raw materials:

(2S,3S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-1-hydroxymethyl-2-(1H-indol-3-yl)-ethyl]-amide

(2S,3S)-3-Methyl-2-(naphthalene-1-sulfonylamino)-pentanoic acid [(S)-2-(1H-indol-3-yl)-1-(methoxy-methyl-carbamoyl)-ethyl]-amide

1-Naphthalenesulfonyl chloride

N-Cbz-L-Isoleucine

Refernces

• 1、 -. "Production of aldehyde derivatives". . . Retrieved 2008/06/13.