3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98%

Base Information

• Chemical Name: 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98%
• CAS No.: 937717-66-3
• Molecular Formula: C6H6F3N3O
• Molecular Weight: 193.1265496
• Hs Code.: 29331990
• Mol file: 937717-66-3.mol

Synonyms:3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98%;3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide;1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide

Chemical Property of 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98%

Chemical Property:

• Boiling Point: 287.4±40.0 °C(Predicted)
• PKA: 14.95±0.50(Predicted)
• PSA: 60.91000
• Density: 1.56±0.1 g/cm3(Predicted)
• LogP: 1.23810

Purity/Quality:

97% ^*data from raw suppliers

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylicacidamide 95%+ ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 3-9-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98%

There total 5 articles about 3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide ,98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride (126674-98-4) → 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (937717-66-3)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran;

Reference yield:

ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (111493-74-4) → 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (937717-66-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium permanganate / water / 20 °C / pH 1

2: thionyl chloride / 4 h / Reflux

3: ammonium hydroxide / tetrahydrofuran

With ammonium hydroxide; potassium permanganate; thionyl chloride; In tetrahydrofuran; water;

Reference yield:

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (113100-53-1) → 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (937717-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / Reflux

2: ammonium hydroxide / tetrahydrofuran

With ammonium hydroxide; thionyl chloride; In tetrahydrofuran;

upstream raw materials:

ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate

1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride

ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate