Welcome to LookChem.com Sign In|Join Free
  • or

Encyclopedia

Technology Process of UNC2250

UNC2250

Base Information
UNC2250

Synonyms:UNC2250;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol;(1r,4r)-4-((2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol;trans-4-[[2-(Butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]cyclohexanol UNC2250

Suppliers and Price of UNC2250
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol
  • 50mg
  • $ 640.00
  • DC Chemicals
  • UNC2250 >98%
  • 100 mg
  • $ 500.00
  • DC Chemicals
  • UNC2250 >98%
  • 250 mg
  • $ 1000.00
  • Crysdot
  • UNC2250 98+%
  • 50mg
  • $ 440.00
  • Crysdot
  • UNC2250 98+%
  • 100mg
  • $ 766.00
  • ChemScene
  • UNC2250 99.96%
  • 100mg
  • $ 740.00
  • ChemScene
  • UNC2250 99.96%
  • 10mg
  • $ 120.00
  • ChemScene
  • UNC2250 99.96%
  • 5mg
  • $ 70.00
  • ChemScene
  • UNC2250 99.96%
  • 50mg
  • $ 440.00
  • Chemenu
  • trans-4-[[2-(Butylamino)-5-[5-(morpholinomethyl)-2-pyridyl]-4-pyrimidinyl]amino]cyclohexanol 98%
  • 50mg
  • $ 361.00
Total 15 raw suppliers
Chemical Property of UNC2250
Chemical Property:
  • Boiling Point:657.4±65.0 °C(Predicted) 
  • PKA:15.02±0.40(Predicted) 
  • PSA：101.89000 
  • Density:1.224±0.06 g/cm3(Predicted) 
  • LogP:2.07990 
  • Storage Temp.:Refrigerator, under inert atmosphere 
  • Solubility.:Chloroform (Slightly, Heated), Ethyl Acetate (Slightly, Heated), Methanol (Sligh 
Purity/Quality:

99%, *data from raw suppliers

(1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Description Tyro3, Axl, and Mer are members of the TAM family of receptor tyrosine kinases that have signaling roles in normal and malignant cells. UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM. It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines. UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.
  • Uses (1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol inhibits steady-state phosphorylation of endogenous Mer and blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. (1r,4r)-4-((2-(Butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-yl)amino)cyclohexanol also decreases colony-forming potential in rhabdoid and NSCLC tumor cells.
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1 Customer Service

What can I do for you?
Get Best Price

Get Best Price for 1493694-70-4

Total 8 Pictures about this product