Chemical Property of 2-Chloro-5-hydroxyphenylglycine
Chemical Property:
- PSA：83.55000
- LogP:1.83030
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥10mg/mL
- XLogP3:-1.4
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:201.0192708
- Heavy Atom Count:13
- Complexity:200
- Purity/Quality:
-
97% *data from raw suppliers
CHPG *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=C(C=C1O)C(C(=O)O)N)Cl
-
Description
(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 μM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 μM, respectively) but not ionotropic glutamate receptors. It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells. In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.
-
Uses
CHPG is a selective mGluR-5 agonist.
