5-Chloro-3,3-diMethylindoline

Base Information

• Chemical Name: 5-Chloro-3,3-diMethylindoline
• CAS No.: 1243165-15-2
• Molecular Formula: C10H12ClN
• Molecular Weight: 181.665
• Hs Code.: 2933990090
• Mol file: 1243165-15-2.mol

Synonyms:5-Chloro-3,3-diMethylindoline

Chemical Property of 5-Chloro-3,3-diMethylindoline

Chemical Property:

• PSA: 12.03000
• LogP: 3.18110

Purity/Quality:

≥99% ^*data from raw suppliers

5-Chloro-3,3-dimethylindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-3,3-diMethylindoline

There total 3 articles about 5-Chloro-3,3-diMethylindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-3,3-dimethylindolin-2-one (74492-46-9) → 5-chloro-3,3-dimethylindoline (1243165-15-2)

Guidance literature:

5-chloro-3,3-dimethylindolin-2-one; With sodium tetrahydroborate; In tetrahydrofuran; for 0.166667h;

With iodine; In tetrahydrofuran; at -10 - 20 ℃; Cooling with acetone-dry ice;

With ammonium chloride; In tetrahydrofuran; chloroform; water;

Reference yield:

C10H13ClN2 (502885-31-6) → 5-chloro-3,3-dimethylindoline (1243165-15-2)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2012.01.117

Reference yield:

N-4-chlorophenylhydrazine (1073-69-4) → 5-chloro-3,3-dimethylindoline (1243165-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 40 °C

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2012.01.117

upstream raw materials:

5-chloro-3,3-dimethylindolin-2-one

C₁₀H₁₃ClN₂

N-4-chlorophenylhydrazine