4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

Base Information

Chemical Name:4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE
CAS No.:1015609-83-2
Molecular Formula:C16H24ClIN2Si
Molecular Weight:434.823
Hs Code.:2933990090
Mol file:1015609-83-2.mol

Synonyms:4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

Suppliers and Price of 4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
50mg
$ 155.00

Sigma-Aldrich
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine Aldrich
1g
$ 637.00

Matrix Scientific
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
150mg
$ 192.00

Crysdot
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 95+%
1g
$ 904.00

Chemenu
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 95%
1g
$ 853.00

American Custom Chemicals Corporation
4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO-[2,3-B]-PYRIDINE 95.00%
100MG
$ 460.95

AK Scientific
4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
250mg
$ 477.00

Total 6 raw suppliers

Chemical Property of 4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

Chemical Property:

PSA：17.82000
LogP:6.31790

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-Chloro-5-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine is used as a reactant in the synthesis of bicyclic heteroaromatic compounds as kinase inhibitors.

Technology Process of 4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE

There total 2 articles about 4-CHLORO-5-IODO-1-(TRIISOPROPYLSILYL)-1H-PYRROLO[2,3-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1015609-83-2
4-chloro-5-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 0 °C

2.1: sec.-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: 0.5 h / -78 - 0 °C

With sec.-butyllithium; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 55052-28-3
4-chloro-7-azaindole

: 1015609-83-2
4-chloro-5-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 °C

2.1: sec.-butyllithium / tetrahydrofuran / 2 h / -78 °C

2.2: 1.5 h / -78 °C

With sec.-butyllithium; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 1015609-83-2
4-chloro-5-iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine

: 1420885-83-1
N-methyl-2-[2-(6-morpholin-4-ylpyridin-3-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-ylamino]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 5 °C

3: copper(l) iodide / N,N-dimethyl-formamide / 2 h / 100 °C

4: n-butyllithium / tetrahydrofuran / 0.5 h / -45 - 40 °C

5: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; caesium carbonate / 1,4-dioxane; water / 12 h / 60 °C

6: palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere

7: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 5 h / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; hydrogenchloride; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; palladium diacetate; sodium hydride; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm3016014