(2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID

Base Information

• Chemical Name: (2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID
• CAS No.: 160141-23-1
• Molecular Formula: C20H31NO5
• Molecular Weight: 365.47
• Mol file: 160141-23-1.mol

Synonyms:(2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID;(αS)-α-[[(2S,3S)-2-[[(1,1-DiMethylethoxy)carbonyl]aMino]-3-Methylpentyl]oxy]benzenepropanoic Acid

Chemical Property of (2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID

Chemical Property:

• Melting Point: 61-63°C
• Boiling Point: 511.0±40.0 °C(Predicted)
• PKA: 3.48±0.10(Predicted)
• PSA: 88.35000
• Density: 1.091±0.06 g/cm3(Predicted)
• LogP: 3.84270
• Solubility.: Methanol

Purity/Quality:

99% ^*data from raw suppliers

(2S)-[(2''S)-t-Boc-amino-(3''S)-methyl-1-pentyloxy]-3-phenylpropionicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID

There total 2 articles about (2S)-[(2'S)-T-BOC-AMINO-(3'S)-METHYL-1-PENTYLOXY]-3-PHENYLPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(tert-Butoxycarbonyl)-2(S)-benzyl-5(S)-[1(S)-methyl]propyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-3-one → N-(tert-butoxycarbonyl)-2(S)-[2(S)-amino-3(S)-methyl]pentyloxy-3-phenyl-propionic acid (160141-23-1)

Guidance literature:

With lithium hydroxide; water; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield: 75.0%

(2S,5S)-2-Benzyl-5-((S)-sec-butyl)-3-oxo-morpholine-4-carboxylic acid tert-butyl ester → N-(tert-butoxycarbonyl)-2(S)-[2(S)-amino-3(S)-methyl]pentyloxy-3-phenyl-propionic acid (160141-23-1)

Guidance literature:

With lithium hydroperoxide; In tetrahydrofuran; water;

DOI:10.1016/0040-4039(95)00687-8

Reference yield: 80.0%

L-homoserine lactone hydrochloride (2185-03-7) + N-(tert-butoxycarbonyl)-2(S)-[2(S)-amino-3(S)-methyl]pentyloxy-3-phenyl-propionic acid (160141-23-1) → N-(tert-butoxycarbonyl)-2(S)-[2(S)-amino-3(S)-methyl]-pentyloxy-3-phenyl-propionyl-homoserine lactone (160141-24-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 16h; pH=6.5;

Downstream raw materials:

N-(tert-butoxycarbonyl)-2(S)-[2(S)-amino-3(S)-methyl]-pentyloxy-3-phenyl-propionyl-homoserine lactone