1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid
CAS No.:296899-02-0
Molecular Formula:C15H15BrN2O2S
Molecular Weight:367.266
Hs Code.:2934100090
DSSTox Substance ID:DTXSID00391122
Wikidata:Q82188368
ChEMBL ID:CHEMBL1699500
Mol file:296899-02-0.mol

Synonyms:296899-02-0;1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid;1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylic acid;1-[4-(4-bromophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylic Acid;CHEMBL1699500;Cambridge id 6999087;Oprea1_302345;SCHEMBL2557611;DTXSID00391122;ZLJCOCPMGGSXRR-UHFFFAOYSA-N;1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylicacid;WLA89902;BDBM50352634;MFCD01990266;AKOS003269690;KB-0729;MB02187;NCGC00183568-01;CS-0323754

Suppliers and Price of 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
1 g
$ 288.00

SynQuest Laboratories
1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid
5 g
$ 509.00

Matrix Scientific
1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylic acid >95%
5g
$ 1040.00

Matrix Scientific
1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylic acid >95%
1g
$ 454.00

Matrix Scientific
1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-4-piperidinecarboxylic acid >95%
500mg
$ 362.00

Crysdot
1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylicacid 95+%
1g
$ 377.00

Chemenu
1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylicacid 95%
1g
$ 356.00

Alichem
1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylicacid
1g
$ 400.00

AK Scientific
1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylicacid
5g
$ 1454.00

Total 8 raw suppliers

Chemical Property of 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Chemical Property:

Melting Point:192～194℃
PSA：81.67000
LogP:3.93860
Storage Temp.:2-8°C
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:366.00376
Heavy Atom Count:21
Complexity:369

Purity/Quality:

97% ^*data from raw suppliers

1-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]piperidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1C(=O)O)C2=NC(=CS2)C3=CC=C(C=C3)Br

Technology Process of 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

There total 3 articles about 1-(4-(4-Bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207618-17-4
ethyl 1-(4-bromothiazol-2-yl)piperidine-4-carboxylate

: 296899-02-0
1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 0.5 h / 100 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran; water / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium hydroxide; In tetrahydrofuran; water; acetonitrile; 1: Suzuki coupling;
DOI:10.1021/jm200497t

Reference yield:

: 1331744-99-0
ethyl 1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylate

: 296899-02-0
1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Guidance literature:: ethyl 1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylate; With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 24h;

With hydrogenchloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm200497t

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 296899-02-0
1-(4-(4-bromophenyl)thiazol-2-yl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 0.5 h / 100 °C / Microwave irradiation

3: lithium hydroxide / tetrahydrofuran; water / 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 2: Suzuki coupling;
DOI:10.1021/jm200497t