(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide

Base Information

Chemical Name:(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide
CAS No.:915205-76-4
Molecular Formula:C₁₉H₂₂N₂O₂
Molecular Weight:310.396
Hs Code.:
Mol file:915205-76-4.mol

Synonyms:(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl aMide 99% (HPLC)

Suppliers and Price of (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID DIBENZYL AMIDE 95.00%
100MG
$ 584.79

Total 4 raw suppliers

Chemical Property of (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide

Chemical Property:

PSA：52.57000
LogP:2.26700
Storage Temp.:2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID DIBENZYL AMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide

There total 7 articles about (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid dibenzyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,4R)-2-Dibenzylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

: 915205-76-4
(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid dibenzylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1002/anie.200602207

Reference yield:

: (2R,4S)-2-Dibenzylcarbamoyl-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

: 915205-76-4
(+/-)-(2S,4R)-2-Bn₂NCO-4-OH-pyrrolidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; under 760 Torr;
DOI:10.1002/anie.200602207

Reference yield:

: (+/-)-N-(benzyloxycarbonyl)-trans-4-hydroxy-L-proline

: 915205-76-4
(+/-)-(2S,4R)-2-Bn₂NCO-4-OH-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: EDC; HOBt / CH₂Cl₂ / 0 - 20 °C

2: H₂ / Pd/C / ethyl acetate / 20 °C / 760 Torr

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1002/anie.200602207