1-(5-fluoropentyl)-1H-indole-3-carboxylic acid

Base Information

• Chemical Name: 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid
• CAS No.: 1432794-98-3
• Molecular Formula: C₁₄H₁₆FNO₂
• Molecular Weight: 249.285
• Mol file: 1432794-98-3.mol

Synonyms:1-(5-fluoropentyl)-1H-indole-3-carboxylic acid;5-fluoro PB-22 3-carboxyindole metabolite

Chemical Property of 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid

Chemical Property:

• PSA: 42.23000
• LogP: 3.47930
• Storage Temp.: -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Fluoro PB-22 3-carboxyindole metabolite solution 100?μg/mL in acetonitrile, certified reference material, ampule of 1?mL, Cerilliant? ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid

There total 8 articles about 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C15H15F4NO → 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid (1432794-98-3)

Guidance literature:

With sodium hydroxide; In methanol; at 80 ℃; for 22h;

Reference yield:

indole (120-72-9) → 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid (1432794-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

1.3: 1 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 18 h / Reflux; Inert atmosphere

With water; sodium hydride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acschemneuro.7b00267

Reference yield:

1-bromo-5-fluoropentane (407-97-6) → 1-(5-fluoropentyl)-1H-indole-3-carboxylic acid (1432794-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 - 20 °C / Inert atmosphere

1.3: 1 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 18 h / Reflux; Inert atmosphere

With water; sodium hydride; sodium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/acschemneuro.7b00267

upstream raw materials:

indole

1-bromo-5-fluoropentane

indole-3-carboxylic acid ethyl ester

3-methoxycarbonylindole

Refernces

• 1、 -. "Synthesis method of 5F-EMB-PICA". . . Retrieved 2021/06/02.
• 2、 Ametovski, Adam,Macdonald, Christa,Manning, Jamie J.,Haneef, S. A. Syed,Santiago, Marina,Martin, Lewis,Sparkes, Eric,Reckers, Andrew,Gerona, Roy R.,Connor, Mark,Glass, Michelle,Banister, Samuel D.. "Exploring Stereochemical and Conformational Requirements at Cannabinoid Receptors for Synthetic Cannabinoids Related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA". . p. 3672 - 3682. Retrieved 2020/11/18.