6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride

Base Information

Chemical Name:6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride
CAS No.:299433-10-6
Molecular Formula:C₂₅H₂₅N₃O₂S
Molecular Weight:431.558
Hs Code.:
Mol file:299433-10-6.mol

Synonyms:6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride;NPS ALX Compound 4a dihydrochloride

Suppliers and Price of 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NPS ALX Compound 4a dihydrochloride
10mg
$ 466.00

ChemScene
NPSALXCompound4a >99.0%
5mg
$ 210.00

ApexBio Technology
NPSALXCompound4adihydrochloride
5mg
$ 331.00

American Custom Chemicals Corporation
NPS ALX COMPOUND 4A DIHYDROCHLORIDE 95.00%
100MG
$ 1963.50

American Custom Chemicals Corporation
NPS ALX COMPOUND 4A DIHYDROCHLORIDE 95.00%
10MG
$ 750.75

Total 6 raw suppliers

Chemical Property of 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride

Chemical Property:

Boiling Point:662.2±65.0 °C(Predicted)
PKA:8.65±0.20(Predicted)
PSA：53.93000
Density:1.36±0.1 g/cm3(Predicted)
LogP:7.00360
Storage Temp.:Store at +4°C

Purity/Quality:

97% ^*data from raw suppliers

NPS ALX Compound 4a dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses NPS ALX Compound 4a dihydrochloride is a competitive SR-6 antagonist.

Technology Process of 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride

There total 4 articles about 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indoledihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 85-46-1
1-Naphthalenesulfonyl chloride

: 299433-01-5
2-(1H-indol-6-yl)-octahydropyrrolo[1,2-a]pyrazine

: 299433-10-6
2-(1-(naphthalen-1-ylsulfonyl)-1H-indol-6-yl)octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: 2-(1H-indol-6-yl)-octahydropyrrolo[1,2-a]pyrazine; With sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 0.25h;

1-Naphthalenesulfonyl chloride; In tetrahydrofuran;

Reference yield:

: 52415-29-9
6-bromo-1H-indole

: 299433-10-6
2-(1-(naphthalen-1-ylsulfonyl)-1H-indol-6-yl)octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 0 °C

2: NaOt-Bu; Pd(OAc)2; t-Bu₃P / xylene / 120 °C

3: TBAF / tetrahydrofuran

4: NaHMDS / tetrahydrofuran

With palladium diacetate; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; sodium hydride; sodium t-butanolate; In tetrahydrofuran; N,N-dimethyl-formamide; xylene; 1: silylation / 2: Condensation / 3: desilylation / 4: sulfonylation;
DOI:10.1016/S0960-894X(00)00320-6

Reference yield:

: 299432-99-8
6-bromo-1-(triisopropylsilyl)-1H-indole

: 299433-10-6
2-(1-(naphthalen-1-ylsulfonyl)-1H-indol-6-yl)octahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: NaOt-Bu; Pd(OAc)2; t-Bu₃P / xylene / 120 °C

2: TBAF / tetrahydrofuran

3: NaHMDS / tetrahydrofuran

With palladium diacetate; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; sodium t-butanolate; In tetrahydrofuran; xylene; 1: Condensation / 2: desilylation / 3: sulfonylation;
DOI:10.1016/S0960-894X(00)00320-6