9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine

Base Information

Chemical Name:9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine
CAS No.:132722-94-2
Molecular Formula:C11H14FN5O2
Molecular Weight:267.2595632
Hs Code.:
Mol file:132722-94-2.mol

Synonyms:6-Amino-8-methyl-9-(2,3-dideoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine;9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine

Suppliers and Price of 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine

Chemical Property:

Melting Point:208 - 209 °C (acetone)
PSA：99.08000
LogP:0.91600

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine

There total 3 articles about 9-(2-Fluoro-2,3-dideoxy-β-D-threo-pentofuranosyl)-8-methyl-9H-purine-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132723-10-5
9-[(2R,3S,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-fluoro-tetrahydro-furan-2-yl]-8-methyl-9H-purin-6-ylamine

: 132722-94-2
8-methyl-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)adenine

Guidance literature:: With acetic acid; at 90 ℃; for 0.666667h; Yield given;
DOI:10.1021/jm00109a018

Reference yield:

: 125542-18-9
6-amino-9-<5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-2'-fluoro-β-D-threo-pentofuranosyl>-9H-purine

: 132722-94-2
8-methyl-9-(2',3'-dideoxy-2'-fluoro-β-D-arabinofuranosyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 15 min

2: aq. acetic acid / 0.67 h / 90 °C

With acetic acid; lithium diisopropyl amide;
DOI:10.1021/jm00109a018