TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE
• CAS No.: 908334-28-1
• Molecular Formula: C15H22N2O2
• Molecular Weight: 262.352
• Hs Code.: 2933990090
• Mol file: 908334-28-1.mol

Synonyms:TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE;3-(4-Amino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property of TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 397.8±42.0 °C(Predicted)
• PKA: 4.96±0.10(Predicted)
• PSA: 55.56000
• Density: 1.123±0.06 g/cm3(Predicted)
• LogP: 3.51230
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 3-(4-aminophenyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE

There total 7 articles about TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

C29H32N2O2 (1428760-69-3) → tert-butyl 3-(4-aminophenyl)pyrrolidine-1-carboxylate (908334-28-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; water; under 22801.5 Torr;

Reference yield:

tert-butyl 3-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate (1393901-75-1) → tert-butyl 3-(4-aminophenyl)pyrrolidine-1-carboxylate (908334-28-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃;

Reference yield:

4-nitrophenylboronic acid (24067-17-2) + 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → tert-butyl 3-(4-aminophenyl)pyrrolidine-1-carboxylate (908334-28-1)

Guidance literature:

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

With N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; at -78 - 20 ℃; for 4h;

4-nitrophenylboronic acid;

upstream raw materials:

4-nitrophenylboronic acid

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

N,N-dibenzyl-4-bromoaniline

C₂₉H₃₄N₂O₃

Downstream raw materials:

(RS)-3-[4-(3-phenyl-ureido)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

(RS)-3-{4-[2-(4-chloro-phenyl)-ethoxycarbonylamino]-phenyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

(RS)-3-(4-isocyanato-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(RS)-3-(4-phenoxycarbonylamino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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