(R)-1-methylpiperidin-3-amine

Base Information

• Chemical Name: (R)-1-methylpiperidin-3-amine
• CAS No.: 1001353-92-9
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• DSSTox Substance ID: DTXSID20428661
• Wikidata: Q82241475
• Mol file: 1001353-92-9.mol

Synonyms:1001353-92-9;(R)-1-methylpiperidin-3-amine;(3R)-1-methylpiperidin-3-amine;(R)-3-AMINO-1-METHYL-PIPERIDINE;(R)-1-Methyl-piperidin-3-ylamine;(R)-3-Amino-1-methylpiperidine;3-Piperidinamine, 1-methyl-, (3R)-;SCHEMBL1269108;DTXSID20428661;(R)-1-methylpiperidin-3-ylamine;QZSACHHNFDNCNB-ZCFIWIBFSA-N;MFCD17015901;AKOS017343493;DS-7752;AC-29540;AM20070636;CS-0030803;P12011;EN300-2995137;A897587

Chemical Property of (R)-1-methylpiperidin-3-amine

Chemical Property:

• Boiling Point: 136.5±8.0 °C(Predicted)
• PKA: 10.40±0.20(Predicted)
• PSA: 29.26000
• Density: 0.912±0.06 g/cm3(Predicted)
• LogP: 0.67750
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 72.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-3-Amino-1-methylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC(C1)N
• Isomeric SMILES: CN1CCC[C@H](C1)N
• Uses: (3R)-1-Methyl-3-piperidinamine is used in preparation of Ph benzoimidazole derivatives as antitumor agents.

Technology Process of (R)-1-methylpiperidin-3-amine

There total 2 articles about (R)-1-methylpiperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(R)-piperidin-3-ylcarbamic acid tert-butyl ester (309956-78-3,172603-05-3) → (R)-1-methylpiperidin-3-amine (1001353-92-9)

Guidance literature:

With formaldehyd; sodium cyanoborohydride; In methanol; water; at 20 ℃;

Reference yield:

→ (R)-1-methylpiperidin-3-amine (1001353-92-9)

Guidance literature:

Reference yield: 78.0%

(R)-1-methylpiperidin-3-amine (1001353-92-9) + 5-chloro-N-(4-morpholino-2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide → (R)-5-((1-methylpiperidin-3-yl)amino)-N-(4-morpholino-2-(trifluoromethyl)phenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

Guidance literature:

With potassium fluoride; In dimethyl sulfoxide; at 40 ℃; for 2h;

DOI:10.1016/j.bmc.2021.116422

upstream raw materials:

(R)-piperidin-3-ylcarbamic acid tert-butyl ester

Downstream raw materials:

C₂₂H₂₄BrN₃

C₂₃H₂₆BrN₃

Refernces

• 1、 -. "PYRROLOTRIAZINE KINASE INHIBITORS". Page/Page column 72. . Retrieved 2011/04/19.