(R)-b-AMino-3-fluorobenzenepropanol

Base Information

• Chemical Name: (R)-b-AMino-3-fluorobenzenepropanol
• CAS No.: 774243-59-3
• Molecular Formula: C9H12FNO
• Molecular Weight: 169.199
• Mol file: 774243-59-3.mol

Synonyms:(R)-b-AMino-3-fluorobenzenepropanol;(2R)-2-AMINO-3-(3-FLUOROPHENYL)PROPAN-1-OL

Chemical Property of (R)-b-AMino-3-fluorobenzenepropanol

Chemical Property:

• PSA: 46.25000
• LogP: 1.38810

Purity/Quality:

98% ^*data from raw suppliers

(R)-2-Amino-3-(3-fluorophenyl)propan-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-b-AMino-3-fluorobenzenepropanol

There total 1 articles about (R)-b-AMino-3-fluorobenzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

(R)-2-amino-3-(3-fluorophenyl)propionic acid (110117-84-5,2629-54-1) → (R)-2-amino-3-(3-fluorophenyl)-1-propanol (774243-59-3)

Guidance literature:

(R)-2-amino-3-(3-fluorophenyl)propionic acid; With borane-THF; In tetrahydrofuran; at 0 - 25 ℃; for 5h;

With sodium hydrogencarbonate; In water; for 15h;

Reference yield: 74.0%

(R)-2-amino-3-(3-fluorophenyl)-1-propanol (774243-59-3) + tert-butylchlorodiphenylsilane (58479-61-1) → C25H30FNOSi (774244-02-9)

Guidance literature:

With 1H-imidazole; In DMF (N,N-dimethyl-formamide);

Reference yield: 74.0%

(R)-2-amino-3-(3-fluorophenyl)-1-propanol (774243-59-3) + tert-butylchlorodiphenylsilane (58479-61-1) → C15H26FNOSi

Guidance literature:

With 1H-imidazole; In DMF (N,N-dimethyl-formamide);

upstream raw materials:

(R)-2-amino-3-(3-fluorophenyl)propionic acid

Downstream raw materials:

C₂₅H₃₀FNOSi

C₁₇H₁₈FNO₃

Refernces

• 1、 Guo, Chuangxing,Hou, Xinjun,Dong, Liming,Dagostino, Eleanor,Greasley, Samantha,Ferre, RoseAnn,Marakovits, Joseph,Johnson, M. Catherine,Matthews, David,Mroczkowski, Barbara,Parge, Hans,VanArsdale, Todd,Popoff, Ian,Piraino, Joseph,Margosiak, Stephen,Thomson, James,Los, Gerrit,Murray, Brion W.. "Structure-based design of novel human Pin1 inhibitors (I)". scheme or table. p. 5613 - 5616. Retrieved 2010/04/30.
• 2、 -. "PHOSPHATE/SULFATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PROTEIN INTERACTING NIMA (PIN1)". Page 62. . Retrieved 2010/02/08.