N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Base Information

• Chemical Name: N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide
• CAS No.: 1235406-89-9
• Molecular Formula: C17H14F3N3O4S2
• Molecular Weight: 445.443
• Hs Code.: 2935009090
• Mol file: 1235406-89-9.mol

Synonyms:N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Chemical Property of N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

Chemical Property:

• PSA: 118.24000
• LogP: 4.44890
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

N-[(2,4-Dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide

There total 5 articles about N-(2,4-diMethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1235406-89-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield: 80.0%

2,4,5-trifluorobenzene-1-sulfonyl chloride (220227-21-4) + N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine (1063733-41-4) → N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1235406-89-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b01918

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → N-[(2,4-dimethoxyphenyl)methyl]-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzene-1-sulfonamide (1235406-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 16 h / Reflux; Dean-Stark

2: sodium tetrahydroborate / methanol / 16 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -78 - 20 °C

With sodium tetrahydroborate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; toluene;

DOI:10.1021/acsmedchemlett.5b00447

upstream raw materials:

2,4-Dimethoxybenzaldehyde

2,4,5-trifluorobenzene-1-sulfonyl chloride

N-[(2,4-dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

Downstream raw materials:

4-(4-chloro-2-(7-(4-methoxybenzyl)-8-oxo-7,8-dihydroimidazo[1,5-a]pyrazin-5-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

4-(2-(1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

4-(4-chloro-2-(2-oxoindolin-5-yl)phenoxy)-N-(2,4-dimethoxybenzyl)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

4-(4-chloro-2-(pyrazolo[1,5-a]pyrimidin-3-yl)phenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide