2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate

Base Information

Chemical Name:2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate
CAS No.:858840-42-3
Molecular Formula:C₈H₇NO₆S
Molecular Weight:245.213
Hs Code.:
Mol file:858840-42-3.mol

Synonyms:2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate;dimethyl3-nitrothiophene-2,5-dicarboxylate

Suppliers and Price of 2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2,5-Dimethyl3-nitrothiophene-2,5-dicarboxylate
250mg
$ 120.00

Crysdot
2,5-Dimethyl3-nitrothiophene-2,5-dicarboxylate 95+%
5g
$ 447.00

Chemenu
2,5-Dimethyl3-nitrothiophene-2,5-dicarboxylate 95%
5g
$ 422.00

AK Scientific
2,5-Dimethyl3-nitrothiophene-2,5-dicarboxylate
1g
$ 231.00

Total 4 raw suppliers

Chemical Property of 2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate

Chemical Property:

PSA：126.66000
LogP:1.75270

Purity/Quality:

98%+ ^*data from raw suppliers

2,5-Dimethyl3-nitrothiophene-2,5-dicarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate

There total 2 articles about 2,5-DiMethyl 3-nitrothiophene-2,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 4282-34-2
Dimethyl thiophene-2,5-dicarboxylate

: 858840-42-3
dimethyl 3-nitrothiophene-2,5-dicarboxylate

Guidance literature:: With sulfuric acid; nitric acid;
DOI:10.1021/acs.jmedchem.6b01869

Reference yield:

: 4282-31-9
Thiophene-2,5-dicarboxylic acid

: 858840-42-3
dimethyl 3-nitrothiophene-2,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 4 h / 20 - 60 °C

2: sulfuric acid; nitric acid

With thionyl chloride; sulfuric acid; nitric acid;
DOI:10.1021/acs.jmedchem.6b01869

Reference yield:

: 858840-42-3
dimethyl 3-nitrothiophene-2,5-dicarboxylate

: 2-(3-methoxyphenethyl)-4-(methylamino)thieno-[3,2-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 20 °C

2: hydrogenchloride / 1,4-dioxane / 90 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

4: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With hydrogenchloride; 20% palladium hydroxide-activated charcoal; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01869