Sacubitril Sodium Salt

Base Information

• Chemical Name: Sacubitril Sodium Salt
• CAS No.: 149690-05-1
• Molecular Formula: C24H28NNaO5
• Molecular Weight: 433.48
• Mol file: 149690-05-1.mol

Synonyms:Sacubitril Sodium Salt

Chemical Property of Sacubitril Sodium Salt

Chemical Property:

• PSA: 99.02000
• LogP: 4.54780
• Storage Temp.: -20°C, Hygroscopic
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Sacubitrilsodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sacubitril Sodium Salt is a salt of Sacubitril, an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.

Technology Process of Sacubitril Sodium Salt

There total 18 articles about Sacubitril Sodium Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenyl-methyl)-4-amino-(2R)-methylbutanoic acid ethyl ester calcium salt → α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt (149690-05-1)

Guidance literature:

With sodium acetate; In ethanol; tert-butyl methyl ether; water; at 20 - 30 ℃; Reagent/catalyst; Solvent;

Reference yield: 94.0%

4-{[(2S,4R)-1-((1,1'-biphenyl)-4-yl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid cyclohehylamine salt → α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt (149690-05-1)

Guidance literature:

4-{[(2S,4R)-1-((1,1'-biphenyl)-4-yl)-5-ethoxy-4-methyl-5-oxo-2-pentanyl]amino}-4-oxobutanoic acid cyclohehylamine salt; With phosphoric acid; hydrogen bromide; In Isopropyl acetate; water; for 0.25h;

With sodium ethanolate; In ethanol; at 22 ℃; Solvent; Temperature; Reagent/catalyst;

Reference yield: 93.0%

sacubitril potaasium hemiacetate salt → α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate monosodium salt (149690-05-1)

Guidance literature:

sacubitril potaasium hemiacetate salt; With hydrogenchloride; In water; ethyl acetate; toluene; for 0.25h;

With sodium hydroxide; In ethanol; at 23 ℃;

upstream raw materials:

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Downstream raw materials:

α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate