(R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid

Base Information

• Chemical Name: (R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid
• CAS No.: 1159501-66-2
• Molecular Formula: C12H24NO9P
• Molecular Weight: 357.294021
• Mol file: 1159501-66-2.mol

Synonyms:(R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid;N-(tert-Butoxycarbonyl)-3-(diethoxyphosphoryl)-L-alanine

Chemical Property of (R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid

Chemical Property:

• Boiling Point: 467.5±40.0 °C(Predicted)
• PKA: 3.48±0.10(Predicted)
• Density: 1.201±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-((tert-Butoxycarbonyl)amino)-3-(diethoxyphosphoryl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid

There total 12 articles about (R)-2-((tert-butoxycarbonyl)aMino)-3-(diethoxyphosphoryl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2-(R)-tert-butoxycarbonylamino-3-(diethoxyphosphoryl)-propionic acid methyl ester (851475-17-7) → (R)-2-tert-butoxycarbonylamino-3-(diethoxyphosphoryl)propionic acid (1159501-66-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

(S)-2-tert-butoxycarbonylamino-3-(diethoxy-phosphoryl)-propionic acid methyl ester → (S)-2-tert-butoxycarbonylamino-3-(diethoxy-phosphoryl)-propionic acid (1159501-74-2,1159501-66-2)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

N-t-butoxycarbonyl-3-iodo-D-alanine methyl ester (170848-34-7,889670-02-4) → (S)-2-tert-butoxycarbonylamino-3-(diethoxy-phosphoryl)-propionic acid (1159501-74-2,1159501-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C

With lithium hydroxide monohydrate; In tetrahydrofuran; water;

DOI:10.1021/acs.jmedchem.5b00933

upstream raw materials:

(2-(R)-tert-butoxycarbonylamino-3-hydroxy-propyl)-phosphonic acid diethyl ester

[2-(R)-(tert-butoxycarbonylamino)-3-(2-trimethylsilanyl-ethoxymethoxy)-propyl]-phosphonic acid diethyl ester

N-tert-butyloxycarbonyl-L-serine methyl ester

2-(R)-tert-butoxycarbonylamino-3-chloro-propionic acid methyl ester

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