5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester
CAS No.:83785-77-7
Molecular Formula:C₁₁H₉ClN₂O₃
Molecular Weight:252.657
Hs Code.:
DSSTox Substance ID:DTXSID30510268
Wikidata:Q82368445
Mol file:83785-77-7.mol

Synonyms:83785-77-7;5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester;DTXSID30510268;ethyl 5-chloro-4-oxo-1H-1,6-naphthyridine-3-carboxylate;FT-0709932;Ethyl 5-chloro-4-oxo-1,4-dihydro-1,6-naphthyridine-3-carboxylate

Suppliers and Price of 5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-CHLORO-1,4-DIHYDRO-4-OXO-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 495.29

Total 5 raw suppliers

Chemical Property of 5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester

Chemical Property:

PSA：72.05000
LogP:1.75320
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:252.0301698
Heavy Atom Count:17
Complexity:370

Purity/Quality:

97% ^*data from raw suppliers

5-CHLORO-1,4-DIHYDRO-4-OXO-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CNC2=C(C1=O)C(=NC=C2)Cl

Technology Process of 5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester

There total 3 articles about 5-Chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54132-23-9
diethyl N-(2-chloro-4-pyridyl)aminomethylenemalonate

: 54132-19-3
ethyl 7-chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate

: 83785-77-7
ethyl 5-chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate

Guidance literature:: In diphenylether; at 250 ℃; for 0.333333h; Title compound not separated from byproducts;
DOI:10.1248/cpb.30.2399

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 83785-77-7
ethyl 5-chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 10 h / 90 °C / excess of diethyl ethoxymethylenemalonate

2: diphenyl ether / 0.33 h / 250 °C

In diphenylether;
DOI:10.1248/cpb.30.2399

Reference yield:

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 83785-77-7
ethyl 5-chloro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / 10 h / 90 °C / excess of diethyl ethoxymethylenemalonate

2: diphenyl ether / 0.33 h / 250 °C

In diphenylether;
DOI:10.1248/cpb.30.2399