1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Base Information

• Chemical Name: 1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole
• CAS No.: 150803-17-1
• Molecular Formula: C₁₂H₁₂FN₃O
• Molecular Weight: 233.245
• Mol file: 150803-17-1.mol

Synonyms:1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Chemical Property of 1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

There total 2 articles about 1-(((2R,3S)-2-(2-fluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-Triazole (288-88-0) + C12H17FO7S2 (917246-55-0) → (2R,3S)-2-(2-Fluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane (150803-17-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 65 ℃;

DOI:10.1016/j.jfluchem.2005.12.008

Reference yield:

(2R,3R)-2-(2-Fluoro-phenyl)-1-[1,2,4]triazol-1-yl-butane-2,3-diol → (2R,3S)-2-(2-Fluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane (150803-17-1)

Guidance literature:

With sodium methylate; methanesulfonyl chloride; triethylamine; Yield given. Multistep reaction; 1.) AcOEt, RT, 2.) AcOEt, MeOH, 0 deg C;

DOI:10.1248/cpb.43.432

Reference yield: 47.0%

1,2,3-triazole (288-36-8) + (2R,3S)-2-(2-Fluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane (150803-17-1) → (2R,3R)-2-(2-Fluoro-phenyl)-3-[1,2,3]triazol-2-yl-1-[1,2,4]triazol-1-yl-butan-2-ol + (2R,3R)-2-(2-fluorophenyl)-3-(1H-1,2, 3-triazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1248/cpb.43.432

upstream raw materials:

1,2,4-Triazole

C₁₂H₁₇FO₇S₂

Downstream raw materials:

(2R,3R)-2-(2-fluorophenyl)-3-[(trans-2-phenyl-1,3-dioxan-5-yl)thio]-1-(1H-1,2,4-triazol-1-yl)-2-butanol

1-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

1-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]-2(1H,3H)-imidazolone

2-[(1R,2R)-2-(2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone