1,4-Diguanylcyclohexane 2HCl

Base Information

• Chemical Name: 1,4-Diguanylcyclohexane 2HCl
• CAS No.: 37781-86-5
• Molecular Formula: C₈H₁₆N₄*2ClH
• Molecular Weight: 241.164
• Mol file: 37781-86-5.mol

Synonyms:1,4-Diguanylcyclohexane 2HCl;1,4-Diguanylcyclohexane dihydrochloride

Chemical Property of 1,4-Diguanylcyclohexane 2HCl

Chemical Property:

• Vapor Pressure: 8.39E-06mmHg at 25°C
• Boiling Point: 369°C at 760 mmHg
• Flash Point: 177°C
• PSA: 99.74000
• LogP: 3.86880

Purity/Quality:

99%min ^*data from raw suppliers

1,4-DIGUANYLCYCLOHEXANE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Diguanylcyclohexane 2HCl

There total 4 articles about 1,4-Diguanylcyclohexane 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trans-cyclohexane-1,4-dicarboxylic acid bis(iminomethyl ester) dihydrochloride → trans-cyclohexane-1,4-dicarboxylic acid diamidine dihydrochloride (37781-86-5)

Guidance literature:

With ammonium chloride; In ethanol; Heating;

DOI:10.1007/BF02259361

Reference yield:

transcyclohexane-1,4-dicarboxylic acid amide (20101-86-4,35541-94-7) → trans-cyclohexane-1,4-dicarboxylic acid diamidine dihydrochloride (37781-86-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / 0.33 h / 245 °C

2: 50 percent / SOCl₂ / 36 h / Heating

3: 99 percent / HCl / benzene / 72 h / 20 °C

4: 86 percent / NH₄Cl / ethanol / Heating

With hydrogenchloride; thionyl chloride; ammonium chloride; In ethanol; benzene; 1: Isomerization / 2: Dehydration / 3: Addition / 4: Substitution;

DOI:10.1007/BF02259361

Reference yield:

trans-1,4-cyclohexanedicarbonitrile (6550-85-2) → trans-cyclohexane-1,4-dicarboxylic acid diamidine dihydrochloride (37781-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / HCl / benzene / 72 h / 20 °C

2: 86 percent / NH₄Cl / ethanol / Heating

With hydrogenchloride; ammonium chloride; In ethanol; benzene; 1: Addition / 2: Substitution;

DOI:10.1007/BF02259361

upstream raw materials:

transcyclohexane-1,4-dicarboxylic acid amide

trans-1,4-cyclohexanedicarbonitrile

trans-1,4-di(carboxamido)cyclohexane

Refernces