7-HydroxyMethyl-spiro[3.5]nonane

Base Information

• Chemical Name: 7-HydroxyMethyl-spiro[3.5]nonane
• CAS No.: 1082373-80-5
• Molecular Formula: C10H18O
• Molecular Weight: 154.252
• Mol file: 1082373-80-5.mol

Synonyms:7-HydroxyMethyl-spiro[3.5]nonane;Spiro[3.5]nonane-7-methanol

Chemical Property of 7-HydroxyMethyl-spiro[3.5]nonane

Chemical Property:

• PSA: 20.23000
• LogP: 2.33920

Purity/Quality:

98%Min ^*data from raw suppliers

Spiro[3.5]nonan-7-ylmethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-HydroxyMethyl-spiro[3.5]nonane

There total 2 articles about 7-HydroxyMethyl-spiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

spiro[3.5]nonane-7-carboxylic acid ethyl ester → spiro[3.5]nonan-7-ylmethanol (1082373-80-5)

Guidance literature:

spiro[3.5]nonane-7-carboxylic acid ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 15h;

With water; sodium sulfate; In tetrahydrofuran; at 0 ℃; for 0.5h;

Reference yield:

spiro[3.5]nonane-7-carboxylic acid (1086399-15-6) → spiro[3.5]nonan-7-ylmethanol (1082373-80-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; hexane; at 30 ℃; Inert atmosphere; Cooling with ice;

Reference yield:

spiro[3.5]nonan-7-ylmethanol (1082373-80-5) + p-toluenesulfonyl chloride (98-59-9) → C17H24O3S (1180557-41-8)

Guidance literature:

With trimethylamine hydrochloride; triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

upstream raw materials:

spiro[3.5]nonane-7-carboxylic acid

Downstream raw materials:

C₁₇H₂₄O₃S

Refernces

• 1、 Irie, Osamu,Kosaka, Takatoshi,Kishida, Masashi,Sakaki, Junichi,Masuya, Keiichi,Konishi, Kazuhide,Yokokawa, Fumiaki,Ehara, Takeru,Iwasaki, Atsuko,Iwaki, Yuki,Hitomi, Yuko,Toyao, Atsushi,Gunji, Hiroki,Teno, Naoki,Iwasaki, Genji,Hirao, Hajime,Kanazawa, Takanori,Tanabe, Keiko,Hiestand, Peter C.,Malcangio, Marzia,Fox, Alyson J.,Bevan, Stuart J.,Yaqoob, Mohammed,Culshaw, Andrew J.,Hart, Terance W.,Hallett, Allan. "Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2". scheme or table. p. 5280 - 5284. Retrieved 2009/05/07.