Etilefrine, (R)-

Base Information

Chemical Name:Etilefrine, (R)-
CAS No.:2259-99-6
Molecular Formula:C₁₀H₁₅NO₂
Molecular Weight:181.235
Hs Code.:
UNII:D9741C38XI
DSSTox Substance ID:DTXSID601221289
Nikkaji Number:J365.212B
ChEMBL ID:CHEMBL1160706
Mol file:2259-99-6.mol

Synonyms:Etilefrine, (R)-;D9741C38XI;2259-99-6;UNII-D9741C38XI;Benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-, (R)-;Benzenemethanol, alpha-((ethylamino)methyl)-3-hydroxy-, (alphaR)-;NCGC00016496-01;CAS-534-87-2;3-[(1R)-2-(ethylamino)-1-hydroxyethyl]phenol;CHEMBL1160706;DTXSID601221289;EN300-8139627;(R)-alpha-[(Ethylamino)methyl]-3-hydroxybenzenemethanol;(alphaR)-alpha-[(Ethylamino)methyl]-3-hydroxybenzenemethanol;BENZENEMETHANOL, .ALPHA.-((ETHYLAMINO)METHYL)-3-HYDROXY-, (R)-;BENZENEMETHANOL, .ALPHA.-((ETHYLAMINO)METHYL)-3-HYDROXY-, (.ALPHA.R)-

Suppliers and Price of Etilefrine, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Etilefrine, (R)-

Chemical Property:

PSA：52.49000
LogP:1.42600
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:181.110278721
Heavy Atom Count:13
Complexity:141

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCNCC(C1=CC(=CC=C1)O)O
Isomeric SMILES:CCNC[C@@H](C1=CC(=CC=C1)O)O

Technology Process of Etilefrine, (R)-

There total 1 articles about Etilefrine, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 709-55-7,95585-90-3
etilefrine

: 2259-99-6,95585-90-3
(R)-N-ethylnorphenylephrine

: 95585-90-3
(S)-etilefrine

Guidance literature:

Reference yield: 23.0%

: 2259-99-6,95585-90-3
(R)-N-ethylnorphenylephrine

: 78658-62-5,122341-53-1,122341-54-2
α-<(N-nitrosoethylamino)methyl>-m-hydroxybenzyl alcohol

: 1-(4-diazo-3-oxo-1,5-cyclohexadienyl)-2-(N-nitrosoethylamino)ethanol

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; at 37 ℃; for 4h; Product distribution; time cours of formation of products;
DOI:10.1248/cpb.37.1600

Reference yield:

: 2259-99-6,95585-90-3
(R)-N-ethylnorphenylephrine

: 110205-28-2
(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-ethyl-N-diethylcarbamoyl)amino ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h

2: 67 percent / cesium carbonate / acetone / 48 h / Heating

With caesium carbonate; triethylamine; In tetrahydrofuran; acetone;
DOI:10.1021/jm00394a026