6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine

Base Information

Chemical Name:6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine
CAS No.:917239-29-3
Molecular Formula:C19H16ClN7O5
Molecular Weight:457.82724
Hs Code.:
Mol file:917239-29-3.mol

Synonyms:6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine;9-(2-O-Acetyl-3-azido-5-O-benzoyl-3-deoxy-beta-D-ribofuranosyl)-6-chloro-9H-purine

Suppliers and Price of 6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine

Chemical Property:

PSA：155.18000
LogP:2.29746

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine

There total 3 articles about 6-Chloro-9-(2-O-acetyl-5-O-benzoyl-3-azido-3-deoxy-beta-D-ribofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3-azido-1,2-bis-O-acetyl-5-O-benzoyl-3-deoxy-D-ribofuranose

: 87-42-3
6-chloropurine

: 917239-29-3
9-(3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine

Guidance literature:: 3-azido-1,2-bis-O-acetyl-5-O-benzoyl-3-deoxy-D-ribofuranose; 6-chloropurine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 50 - 60 ℃; for 1h;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 65 - 70 ℃; for 4h;
DOI:10.1080/15257770500267170

Reference yield:

: 917239-30-6
9-(3'-azido-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine

: 917239-29-3
9-(3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84 percent / pyridine / CH₂Cl₂ / -40 °C

2.1: 82 percent / TBAF / tetrahydrofuran / 20 h / 20 °C

3.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 50 - 60 °C

3.2: 90 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / 65 - 70 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1080/15257770500267170

Reference yield:

: 917239-31-7
9-(3'-azido-2'-O-triflyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine

: 917239-29-3
9-(3'-azido-2'-O-acetyl-5'-O-benzoyl-3'-deoxy-β-D-ribofuranosyl)-6-chloro-9H-purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 82 percent / TBAF / tetrahydrofuran / 20 h / 20 °C

2.1: N,O-bis(trimethylsilyl)acetamide / acetonitrile / 1 h / 50 - 60 °C

2.2: 90 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 4 h / 65 - 70 °C

With N,O-bis-(trimethylsilyl)-acetamide; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1080/15257770500267170