4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid

Base Information

• Chemical Name: 4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid
• CAS No.: 936571-71-0
• Molecular Formula: C₁₈H₂₅N₃O₆
• Molecular Weight: 379.413

Synonyms:4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid

Chemical Property of 4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid

Chemical Property:

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Technology Process of 4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid

There total 4 articles about 4-[[bis[[(1,1-dimethylethoxy)carbonyl]amino]methylene]amino]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-carbamimidamidobenzoic acid hydrochloride → 4-{[{[(tert-butoxy)carbonyl]amino}({[(tert-butoxy)carbonyl]imino})methyl]amino}benzoic acid (936571-71-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

Reference yield: 36.0%

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-54-2,862686-58-6,1143572-00-2) → 4-{[{[(tert-butoxy)carbonyl]amino}({[(tert-butoxy)carbonyl]imino})methyl]amino}benzoic acid (936571-71-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; Heating;

DOI:10.1016/j.bmcl.2007.01.004

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) + 1-[(tert-butyloxycarbonylamino)-(tert-butyloxycarbonylimino)-methyl]-1H-pyrazole → 4-{[{[(tert-butoxy)carbonyl]amino}({[(tert-butoxy)carbonyl]imino})methyl]amino}benzoic acid (936571-71-0)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 220h; Inert atmosphere;

upstream raw materials:

4-amino-benzoic acid

N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine

1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine

di-tert-butyl dicarbonate

Downstream raw materials:

2(S)-[2(S)-(4-guanidino-benzoylamino)-3-methyl-butyrylamino]-3-phenyl-propionic acid

C₃₅H₄₆N₈O₅

Fmoc-Dap(4-(2,3-bis(Boc)guanidino)benzoate)-OH

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