tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate
• CAS No.: 859154-32-8
• Molecular Formula: C11H21N3O3
• Molecular Weight: 243.306
• Hs Code.: 2933399090
• Mol file: 859154-32-8.mol

Synonyms:tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate

Chemical Property of tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate

Chemical Property:

• Melting Point: 55 °C
• Boiling Point: 409.2±34.0 °C(Predicted)
• PKA: 13.05±0.20(Predicted)
• PSA: 88.15000
• Density: 1.147±0.06 g/cm3(Predicted)
• LogP: 2.10190
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Boc-piperidine-3-carboxylicacidhydrazide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate

There total 1 articles about tert-butyl 3-(hydrazinecarbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl N-(t-butyloxycarbonyl)nipecotate (148672-74-6,130250-54-3) → 3-hydrazinocarbonyl-piperidine-1-carboxylic acid tert-butyl ester (859154-32-8)

Guidance literature:

With hydrazine hydrate; at 20 ℃; Reflux;

DOI:10.1021/jm701562x

Reference yield: 61.0%

3-hydrazinocarbonyl-piperidine-1-carboxylic acid tert-butyl ester (859154-32-8) + N-(2-formylquinolin-8-yl)-4-(trifluoromethyl)benzenesulfonamide → tert-butyl (E/Z)-3-(2-((8-((4-(trifluoromethyl)phenyl)sulfonamido)quinolin-2-yl)methylene)hydrazine-1-carbonyl)piperidine-1-carboxylate

Guidance literature:

With sodium acetate; In ethanol; water; at 70 ℃; for 18h;

upstream raw materials:

ethyl N-(t-butyloxycarbonyl)nipecotate

Refernces

• 1、 -. "Compounds useful in therapy". Page/Page column 28-29. . Retrieved 2010/02/12.