1-(Biphenyl-2-yl)piperazine dihydrochloride

Base Information

Chemical Name:1-(Biphenyl-2-yl)piperazine dihydrochloride
CAS No.:274673-37-9
Molecular Formula:C16H20Cl2N2
Molecular Weight:252.359
Hs Code.:
European Community (EC) Number:674-814-5
DSSTox Substance ID:DTXSID50998281
Mol file:274673-37-9.mol

Synonyms:769944-87-8;1-(biphenyl-2-yl)piperazine dihydrochloride;1-(2-Biphenyl)piperazine dihydrochloride;274673-37-9;1-(2-Biphenyl)piperazine DiHCl;1-(2-phenylphenyl)piperazine;dihydrochloride;1-(2-Biphenyl)piperazine 2HCl;1-Biphenyl-2-ylpiperazine dihydrochloride;1-([1,1'-Biphenyl]-2-yl)piperazine dihydrochloride;1-{[1,1'-biphenyl]-2-yl}piperazine dihydrochloride;SCHEMBL1673713;Piperazine, 1-[1,1'-biphenyl]-2-yl-, dihydrochloride;DTXSID50998281;RTPHBWZMEINVKF-UHFFFAOYSA-N;MFCD03094588;AKOS025393459;PS-7080;1-biphenyl-2-yl-piperazine dihydrochloride;1-([1,1'-Biphenyl]-2-yl)piperazinedihydrochloride;1-(2-biphenyl)piperazine dihydrochloride, AldrichCPR;1-([1,1'-Biphenyl]-2-yl)piperazine--hydrogen chloride (1/2)

Suppliers and Price of 1-(Biphenyl-2-yl)piperazine dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AHH
1-(2-Biphenyl)piperazinedihydrochloride 97%
5g
$ 240.00

Total 5 raw suppliers

Chemical Property of 1-(Biphenyl-2-yl)piperazine dihydrochloride

Chemical Property:

Melting Point:205-209
PSA：15.27000
LogP:4.76100
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:310.1003540
Heavy Atom Count:20
Complexity:242

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Biphenyl)piperazinedihydrochloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi,N
Statements: 50
Safety Statements: 61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC=CC=C2C3=CC=CC=C3.Cl.Cl

Technology Process of 1-(Biphenyl-2-yl)piperazine dihydrochloride

There total 4 articles about 1-(Biphenyl-2-yl)piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 274673-37-9
1-([1,1'-biphenyl]-2-ylmethyl)piperazine

Guidance literature:: In tetrahydrofuran; for 2.5h; Reflux;

Reference yield:

: 1229247-68-0
tert-butyl 4-([1,1'-biphenyl]-2-ylmethyl)piperazine-1-carboxylate

: 274673-37-9
1-([1,1'-biphenyl]-2-ylmethyl)piperazine

Guidance literature:: tert-butyl 4-([1,1'-biphenyl]-2-ylmethyl)piperazine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4.5h;

With sodium hydroxide; In dichloromethane; water; pH=8 - 9;

Reference yield:

: 3433-80-5
1-Bromo-2-bromomethyl-benzene

: 274673-37-9
1-([1,1'-biphenyl]-2-ylmethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 0.5 h / 100 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 2 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1002/cmdc.201300316