Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate

Base Information

• Chemical Name: Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate
• CAS No.: 4940-37-8
• Molecular Formula: C12H12O5
• Molecular Weight: 236.224
• Hs Code.: 2918990090
• Mol file: 4940-37-8.mol

Synonyms:Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate

Chemical Property of Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate

Chemical Property:

• PSA: 80.67000
• LogP: 1.09720

Purity/Quality:

≥99% ^*data from raw suppliers

Ethyl4-(2-hydroxyphenyl)-2,4-dioxobutanoate 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate

There total 4 articles about Ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + oxalic acid diethyl ester (95-92-1) → ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate (4940-37-8)

Guidance literature:

o-hydroxyacetophenone; With sodium hydride; In toluene; at 20 ℃; for 0.25h;

oxalic acid diethyl ester; In toluene; at 60 ℃; for 2h;

DOI:10.1021/acs.jmedchem.7b00523

Reference yield:

1-phenyl-2-hydroxyethanone (582-24-1) + oxalic acid diethyl ester (95-92-1) → ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate (4940-37-8)

Guidance literature:

With sodium hydride; In toluene; at 50 ℃; for 1h;

DOI:10.1128/AAC.01498-21

Reference yield:

ethyl 2-hydroxy-4-oxochroman-2-carboxylate (65950-31-4) → ethyl 4-(2-hydroxyphenyl)-2,4-dioxobutanoate (4940-37-8)

Guidance literature:

In chloroform-d1; at 20 ℃; for 96h; Product distribution; other time (20 h, 24 h);

upstream raw materials:

o-hydroxyacetophenone

oxalic acid diethyl ester

ethyl 2-hydroxy-4-oxochroman-2-carboxylate

1-phenyl-2-hydroxyethanone

Downstream raw materials:

acide chromone carboxylique-2

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