Chemical Property of Ivermectin B1a
Chemical Property:
- Boiling Point:940.4oC at 760mmHg
- Flash Point:267.3oC
- PSA：170.06000
- Density:1.23g/cm3
- LogP:5.60140
- XLogP3:4.1
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:14
- Rotatable Bond Count:8
- Exact Mass:874.50785703
- Heavy Atom Count:62
- Complexity:1680
- Purity/Quality:
-
98% *data from raw suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Anthelmintic Agents
- Canonical SMILES:CCC(C)C1C(CCC2(O1)CC3CC(O2)CC=C(C(C(C=CC=C4COC5C4(C(C=C(C5O)C)C(=O)O3)O)C)OC6CC(C(C(O6)C)OC7CC(C(C(O7)C)O)OC)OC)C)C
- Isomeric SMILES:CC[C@H](C)[C@@H]1[C@H](CC[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@H]([C@@H](O7)C)O)OC)OC)\C)C
- Recent ClinicalTrials:Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole
- Recent EU Clinical Trials:A multicentre randomised, Double-Blind, Placebo-controlled, Study to evaluate the efficAcy and safety of oral IVErmectin tablets in the prevention of COVID-19 (the SAIVE Trial)
- Recent NIPH Clinical Trials:double-blind study in COvid-19 patients with iveRmectin
-
Uses
Ivermectin B1a (dihydroavermectin B1a) is the major component (>80%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectins and milbemycins are also potent insecticides. The individual 25-sec-butyl (B1a) and 25-iso-propyl (B1b) components of ivermectin have received little separate study.
